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Research Field of the Graduate School

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Infection Control and Immunology course
Masterfs program, Doctoral Program

[ Infection Control and Immunology course ]
March 31, 2013
Professor Research Content

Nakayama Tetsuo
     Research concerning the evaluation of vaccines and molecular epidemiological investigation

     Distrust in vaccines is derived from their adverse reactions. It is necessary to accurately evaluate whether adverse events after vaccination are related to the vaccine. Many instances reported as adverse events are common infections such as respiratory infections and enterovirus infection. Therefore, molecular epidemiological investigations are necessary to understand the pathology and epidemiology of common infections and the properties of wild epidemic strains for using live attenuated measles, mumps, and rubella vaccines. The basic laboratory procedures for RT-PCR, determination of base sequences, and gene recombination are studied, and research under the following themes is conducted.

(1) Molecular epidemiology of
     measles, mumps, enterovirus, and RS virus
(2) Analysis of the mechanism of the attenuated
(3) Designing recombinant vaccines expressing
(4) Antibody epidemiological investigations of
     measles, rubella, mumps, and influenza
(5) Biological activity of the measles virus
(6) Cell fusion abilities of measles and mumps viruses
(7) Rapid diagnosis of viral infections


Morikawa Yuko
     Research on the molecular mechanism of viral replication and its control

     The students are required to choose a theme of interest from the following 1)-5) concerning human viral infections considered to be current threats such as AIDS and influenza. Instructors share their knowledge of and skills related to different areas including molecular biology, biochemistry, and cell biology to allow students to pursue their research themes and assist them in the evaluation and interpretation of results. On the basis of their accomplishments, instructors urge students to plan subsequent experimental strategies. Each student is required to report the state of research progress.

(1) Host factors and molecular mechanisms involved in
     the control of viral replication
(2) Mechanisms of particle formation and the
     maturation of viruses
(3) Molecular basis of the pathology and transmission
     of the HIV infection
(4) Action mechanisms of anti-HIV drugs and drug
(5) Creation of anti-HIV drugs and the molecular
     design of vaccines


Abe Akio
     Research concerning the type III secretion machinery of Gram-negative bacteria and effector functions

     Some pathogenic bacteria produce their pathogenicity by actively transporting various pathogenic factors into host cells. Recent studies have revealed that type III secretion machine is involved in this transport of pathogenic factors into host cells. The special research of molecular bacteriology is conducted by focusing on the mechanisms contributing to the pathogenicity of crosstalk of pathogenic bacteria, genome analysis of pathogenic factors, structure and function of type III secretion machinery, and proteins derived from bacteria transported into host cells. After guidance in the basic techniques of molecular biology and molecular cell biology over approximately 2 months, students are asked to choose a research theme of interest from the following. Instructors serve as guides and assist the students to reach their individual research goals, respect the autonomy of students, provide logistic support for the evaluation of results, and determine the direction of the development of research. To promote improvements in research presentation techniques, research presentation sessions are also held using a projector and other equipment to develop human resources capable of independently pursuing an academic career after the completion of the masterfs course.

(1) Functional analysis of effectors that are
     transported into host cells by
     type III secretion machinery
(2) Functional analysis of the type III
     secretion machinery
(3) Analysis of interactions between effectors and
     host factors

Takahashi Takashi
     Basic and clinical studies on severe infections in communities and hospitals

     Research on the following themes is presently being conducted to promote diagnosis, treatment, prevention, and guidance concerning infections, measures to control health-care-associated infections, the development of antimicrobial drugs, and education and research from a wide perspective.

(1) Clarification of the pathological relationship
     between viruses and pathogenic bacteria
     in respiratory infections
(2) Research on the dissemination pathophysiology in
     invasive streptococcal infections
(3) Development of methods for the rapid detection of
     genes related to the identification of
     bacteria causing sepsis
(4) Research on new treatments for airway
     viral infections
(5) Establishment of evidence leading to
     the effective control of health-care-associated
(3) Research concerning the pathophysiology of
     severe infections with metabolic abnormalities

Drug Discovery Sciences course
Masterfs program, Doctoral Program

[ Drug Discovery Sciences course ]
March 31, 2013

Professor Research Content


Ikeda Haruo
     Laboratory and applied research drug discovery based on microbial genetic information

     To conduct laboratory and applied pharmaceutical research based on microbial genetic information, a research theme is selected from those listed below. Before its selection, all research themes are explained, and basic experiments are carried out.

(1) Genomic analysis of microorganisms producing
     materials with useful biological activities and
     the functional analysis of unknown genes
(2) Proteome analysis and transcription analysis of
     bacteria producing bioactive materials
(3) Application of microbial genetic information for
     the production of materials
(4) Analysis of genes involved in the biosynthesis of
     bioactive materials and analysis of the regulation of
     gene expression
(5) Search for, and functional modification of
     the genes of enzymes useful for the conversion
     of materials
- Training sessions to learn basic computer operations and script language are provided concerning themes requiring gene analysis.


Sunazuka Toshiaki
     Research to discover drugs for infections and important diseases

     Research themes are selected from those listed below concerning the creation of new drugs including anti-infectious drugs by the techniques of organic synthesis using naturally-occurring materials.

(1) Determination of the relative and
     absolute structures of naturally-occurring materials
     with useful biological activities
(2) Establishment of efficient methods for the complete
     synthesis of naturally-occurring materials with
     useful biological activities
(3) Synthetic pharmaceutical research using
     naturally-occurring materials with useful
     biological activities as leads
(4) Synthesis of macrolides with novel actions and
     the elucidation of their mechanisms
(5) Development of non-naturally-occurring bioactive
     materials for the analysis of body and cell functions
(6) Creation of novel functional molecules using
     naturally-occurring bioactive materials
(7) Screening of microorganisms for
     naturally-occurring bioactive materials

Shiomi Kazuro
     Experiments are conducted with research themes such as the following.

(1) Search for materials with novel biological activities
     derived from microorganisms effective for
     the control of infections (viral, bacterial, fungal,
     and parasite infections, and the animals
     transmitting them)
(2) Search for novel bioactive materials derived from
     microorganisms effective for the treatment of
     important diseases (including cancer and
     lifestyle-related diseases)
(3) Clarification of the intracellular target molecules of
     bioactive materials produced by microorganisms
(4) Analysis of cell functions and the mechanisms of
     their control using bioactive materials produced by

Takahashi Yoko
     Exploration of new microbial resources for drug discovery

     The following research themes are addressed with bacteria and actinomycetes as primary targets..

(1) Isolation and classification of unknown and
     unculturable microorganisms
     Research is carried out to develop simple methods for the detection and isolation of rare microorganisms and methods for the selection of useful microorganisms by detecting genes involved in the biosynthesis of secondary metabolites.
(2) Evaluation of culturing for the production of
     bioactive materials
     Culturing conditions such as temperature, ventilation rate, and nutritional conditions are evaluated and applied to the search for bioactive materials. Exhaustive analysis of secondary metabolites is also conducted, and the isolation and purification of produced materials are attempted.
(3) Research on genes that control morphological
     differentiation by the genomic analysis of

Yamada Haruki
     Analysis of pharmacological mechanisms and the use of traditional Japanese and Chinese medicines for the treatment of infections and immunological/neurological disorders

     Regarding the use of traditional Japanese and Chinese medicines and Kampo medicines, research themes are selected from those listed below for the clarification of their pharmaceutical actions and action mechanisms on the molecular level and the identification and application of pharmacologically active ingredients..

(1) Research concerning the comprehensive analysis
     of pharmacological actions, pharmacologically
     active ingredients, and combined effects,
     and the action mechanisms of Kampomedicines
1)  Analysis of the pharmacological effects of Kampo medicines mediated by regulation of the mucosal immune system
2)  Analysis of the pharmacological effects of Kampomedicines on infections including influenza viral infection
3)  Analysis of the pharmacological effects Kampomedicines on disorders of brain functions and psychiatric and neurological disorders

(2) Clarification of the structures of polysaccharides
     as pharmacologically active ingredients of
     traditional Japanese and Chinese drugs and
     the mechanisms of their activities
(3) Development of systems for evaluating the
     pharmacological effects Kampomedicines and
     the search for drug materials with new concepts
     from naturally-occurring materials such as
     traditional Japanese and Chinese medicines