March 31, 2013
March 31, 2013
Distrust in vaccines is derived from their adverse reactions. It is necessary to accurately evaluate whether adverse events after vaccination are related to the vaccine. Many instances reported as adverse events are common infections such as respiratory infections and enterovirus infection. Therefore, molecular epidemiological investigations are necessary to understand the pathology and epidemiology of common infections and the properties of wild epidemic strains for using live attenuated measles, mumps, and rubella vaccines. The basic laboratory procedures for RT-PCR, determination of base sequences, and gene recombination are studied, and research under the following themes is conducted.
The students are required to choose a theme of interest from the following 1)-5) concerning human viral infections considered to be current threats such as AIDS and influenza. Instructors share their knowledge of and skills related to different areas including molecular biology, biochemistry, and cell biology to allow students to pursue their research themes and assist them in the evaluation and interpretation of results. On the basis of their accomplishments, instructors urge students to plan subsequent experimental strategies. Each student is required to report the state of research progress.
Some pathogenic bacteria produce their pathogenicity by actively transporting various pathogenic factors into host cells. Recent studies have revealed that type III secretion machine is involved in this transport of pathogenic factors into host cells. The special research of molecular bacteriology is conducted by focusing on the mechanisms contributing to the pathogenicity of crosstalk of pathogenic bacteria, genome analysis of pathogenic factors, structure and function of type III secretion machinery, and proteins derived from bacteria transported into host cells. After guidance in the basic techniques of molecular biology and molecular cell biology over approximately 2 months, students are asked to choose a research theme of interest from the following. Instructors serve as guides and assist the students to reach their individual research goals, respect the autonomy of students, provide logistic support for the evaluation of results, and determine the direction of the development of research. To promote improvements in research presentation techniques, research presentation sessions are also held using a projector and other equipment to develop human resources capable of independently pursuing an academic career after the completion of the master’s course.
Research on the following themes is presently being conducted to promote diagnosis, treatment, prevention, and guidance concerning infections, measures to control health-care-associated infections, the development of antimicrobial drugs, and education and research from a wide perspective.