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Laboratory of Infectious Diseases Science

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  • Publications

Research Synopsis

 The principle of the Laboratory of Infectious Diseases Science is “Science for society”, i.e., to practice science for the benefit of society (general population or patients with infectious diseases). To reach this goal, it is important for our laboratory to cooperate with communities or medical institutions. We are attempting to transmit to our cooperators hints that may lead to measures against, or solutions to problems concerning infections provided by the clinical staff. Practically, we are conducting research on the diseases of various fields such as respiratory infections, skin and soft tissue infections, zoonoses, and sepsis and infection control in medical institutions. Research is conducted on the following 6 main themes.

  1. The pathophysiology of general dissemination in invasive streptococcal infections
  2. Pathogenic association of viruses with bacteria in the respiratory tract
  3. Pathogenicity of Helicobacter bacteria in humans
  4. Development of novel therapeutic approaches to respiratory viral infections
  5. Pathophysiology of severe infections under metabolic abnormalities such as obesity and diabetes
  6. Establishment of evidence leading to the effective control of health-care-associated infections
proposed process of streptococcal invasiveness from skin into vessels of subcutaneous tissue
Development of severe skin and soft tissue infection 72 hours after the footpad inoculations of Streptococcus pyogenes, a clinically isolated strain, in human CD46 transgenic (hCD46-Tg) mouse


Takashi Takahashi
Takashi Takahashi
Haruno Yoshida
Haruno Yoshida
Research Associate


  1. Takahashi T, Goto M, Yoshida H, Sumino H, Matsui H. : Infectious diseases after the 2011 Great East Japan Earthquake. J Exp Clin Med. 2012; 4: 20-23.
  2. Murayama T, Li Y, Takahashi T, Yamada R, Matsubara K, Tsuchida Y, Zheng X, Sadanari H. : Anti-cytomegalovirus effects of tricin are dependent on CXCL11. Microbes Infect. 2012; 14: 1086-1092.
  3. Okada T, Morozumi M, Sakata H, Takayanagi R, Ishiwada N, Sato Y, Oishi T, Tajima T, Haruta T, Kawamura N, Ouchi K, Matsubara K, Chiba N, Takahashi T, Iwata S, Ubukata K. : A practical approach estimating etiologic agents using real-time PCR in pediatric inpatients with community-acquired pneumonia. J Infect Chemother. 2012; 18: 832-840.
  4. Ishikawa K, Kanazawa Y, Morimoto S, Takahashi T. : Depopulation with rapid aging in Minamisoma city after the Fukushima Daiichi nuclear power plant accident. J Am Geriatr Soc. 2012; 60: 2357-2358.


  1. Hasegawa M, Okada T, Sakata H, Nakayama E, Fuchigami T, Inamo Y, Mugishima H, Tajima T, Iwata S, Morozumi M, Ubukata K, Watanabe H, Takahashi T. : Pandemic (H1N1) 2009-associated pneumonia in children, Japan. Emerg Infect Dis. 2011; 17: 277-280.
  2. Yoshida H, Matsui H, Murayama SY, Takada Y, Matsuo K, Takahashi T, Nakamura M, Ubukata K, Takahashi T. : A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis(SDSE). J Med Microbiol. 2011; 60: 1860-1868.
  3. Takahashi T, Ubukata K, Watanabe H :. Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features. J Infect Chemother. 2011; 17: 1-10.
  4. Takahashi T, Iijima K, Kuzuya M, Hattori H, Yokono K, Morimoto S. : Guidelines for non-medical care providers to manage the first steps of emergency triage of elderly evacuees. Geriatr Gerontol Int. 2011; 11: 383-394.


  1. Takahashi T, Sunaoshi K, Sunakawa K, Fujishima S, Watanabe H, Ubukata K, and the Invasive Streptococcal Disease Working Group. : Clinical aspects of invasive infections with Streptococcus dysgalactiae subsp. equisimilisin Japan: differences with respect to Streptococcus pyogenes and Streptococcus agalactiae. Clin Microbiol Infect. 2010; 16: 1097-1103.
  2. Hasegawa M, Inamo Y, Fuchigami T, Hashimoto K, Morozumi M, Ubukata K, Watanabe H, Takahashi T. : Bronchial casts and pandemic (H1N1) 2009 virus infection. Emerg Infect Dis. 2010; 16: 344-346.
  3. Hasegawa M, Hashimoto K, Morozumi M, Ubukata K, Takahashi T, Inamo Y. : Spontaneous pneumomediastinum complicating pneumonia in children infected with the 2009 pandemic influenza A (H1N1) virus. Clin Microbiol Infect. 2010; 16: 195-199.
  4. Matsui H, Sekiya Y, Aikawa C, Murayama SY, Takahashi T, Yoshida H, Takahashi T, Tsuchimoto K, Nakamura M. : Candidatus Helicobacter heilmannii infection in the course of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in human beings and mouse models. Curr Trends Microbiol. 2010; 6: 27-34.