professor and students smiling in the lab

Laboratory of Biological Functions

  • Research
  • Members
  • Publications

Research Synopsis

 Microorganisms have provided many drugs and useful compounds and are a rich treasure house for drug discovery. Our laboratory focuses on discovering useful bioactive compounds, particularly anti-infectious drugs for bacteria, fungi, parasites, and viruses, from these microbial resources. For this purpose, we are studying themes such as the establishment of an evaluation system to search for new bioactive materials, screening of materials using this evaluation system, analysis of the chemical structures of the metabolic products of microorganisms and their biosynthesis, and identification of the intracellular target molecules of bioactive materials with the discovery of new drugs in mind.


 Search for useful bioactive compounds from microorganisms and the determination of their target molecules

  1. Exploration for anti-infectious drugs (materials that act on bacteria, fungi, parasites,viruses, and hygienically harmful insects that transmit them) derived from microorganisms.
  2. Exploration for bioactive materials (anti-cancer drugs and treatments for lifestyle-related diseases) derived from microorganisms.
  3. Determination of the structures and biosynthesis of useful bioactive compounds.
  4. Elucidation of intracellular target molecules of useful bioactive compounds.
  5. Analysis of body and cell functions using bioactive compounds.
Process from Screening of Microbial Culture Fluid to Isolation of Active Substances

Staff

Shiomi Kazuro
Shiomi Kazuro
Professor
Asami Yukihiro
Project Associate Professor
  • Mori Mihoko
    Assistant Professor

Research Results

2012

  1. J. Hashida, M. Niitsuma, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, I. Ara, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi, S. Omura. : Panowamycins A and B, new anti-trypanosomal isochromans produced by Streptomycessp. K07-0010. J. Antibiot. 65, 197-202 (2012).
  2. M. Ohtawa, K. Sugiyama, T. Hiura, S. Izawa, K. Shiomi, S. Omura. : Stereoselective total synthesis of atpenin A4 and B, harzianopyridone, and NBR123477 B. Chem. Pharm. Bull. 60, 898-906 (2012).
  3. K. Nonaka, H. Miyazaki, M. Iwatsuki, K. Shiomi, H. Tomoda, S. Omura, R. Masuma. : Staphylotrichum boninense, a new hyphomycete (Chaetomiaceae) from soils in the Bonin Islands, Japan. Mycoscience 53, 312-318 (2012).
  4. T. Suga, T. Ishii, M. Iwatsuki, T. Yamamoto, K. Nonaka, R. Masuma, H. Matsui, H. Hanaki, S. Omura, K. Shiomi. : Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6’)/APH(2”). J. Antibiot. 65, 527-529 (2012).
  5. T. Yamamoto, N. Izumi, H. Ui, A. Sueki, R. Masuma, K. Nonaka, T. Hirose, T. Sunazuka, T. Nagai, H. Yamada, S. Omura, K. Shiomi. : Wickerols A and B, novel anti-influenza virus diterpenes produced by Trichoderma atrovirideFKI-3849. Tetrahedron 68, 9267-9271 (2012).
  6. 海渕 覚, 野中健一, 森 美穂子, 塩見和朗, 大村 智, 増間碌郎 : 異種Hypocrea/Trichoderma属菌の共培養による色素生産誘導について. 日本菌学会会報 53, 71-81 (2012).
  7. T. Ishii, K. Nonaka, T. Suga, R. Masuma, S. Omura, K. Shiomi. : Cytosporone S with antimicrobial activity, isolated from the fungus Trichodermasp. FKI-6626. Bioorg. Med. Chem. Lett. 23, 679-681 (2013).
  8. P. Sripreechasak, S. Tanasupawat, K. Suwanborirux, Y. Inahashi, A. Matsumoto, K. Shiomi, Y. Takahashi. : Nonomuraea thailandensissp. nov. isolated from Thai soil. J. Antibiot. (published online) doi:10.1038/ja.2012.96
  9. S. Kaifuchi, K. Nonaka, M. Mori, K. Shiomi, S. Omura, R. Masuma. : Lecanicillium primulinum, a new hyphomycete (Cordycipitaceae) from soils in the Okinawa's main island and the Bonin Islands, Japan. Mycoscience (published online) dx.doi.org/10.1016/j.myc.2012.10.006

2011

  1. Y. Inahashi, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, T. Hirose, T. Sunazuka, H. Yamada, K. Otoguro, Y. Takahashi, S. Omura, K. Shiomi. : Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptomyces oxazolinicumK07-0460T. J. Antibiot. 64, 303-307 (2011).
  2. M. Mori, H. Morimoto, Y.-P. Kim, H. Ui, K. Nonaka, R. Masuma, K. Sakamoto, K. Kita, H. Tomoda, K. Shiomi, S. Omura. : Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicilliumsp. FKI-3389. Tetrahedron 67, 6582-6586 (2011).
  3. T. Hirose, T. Kasai, T. Akimoto, A. Endo, A. Sugawara, K. Nagasawa, K. Shiomi, S. Omura, T. Sunazuka. : Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag. Tetrahedron 67, 6633-6643 (2011).
  4. M. Iwatsuki, T. Ishimori, T. Yamamoto, K. Takata, M. Mori, K. Nonaka, R. Masuma, Y. Hayakawa, H. Hanaki, K. Shiomi, S. Omura. : Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicilliumsp. FKI-4429. Tetrahedron 67, 6644-6648 (2011).
  5. K. Nonaka, R. Masuma, M. Iwatsuki, K. Shiomi, K. Otoguro, S. Omura. : Penicillium viticola, a new species isolated from a grape in Japan. Mycoscience 52, 338-343 (2011).
  6. K. Nonaka, T. Abe, M. Iwatsuki, M. Mori, T. Yamamoto, K. Shiomi, S. Omura, R. Masuma. : Enhancement of metabolites productivity of Penicillium pinophilumFKI-5653, by co-culture with Trichoderma harzianumFKI-5655. J. Antibiot. 64, 769-774 (2011).
  7. T. Ishii, K. Nonaka, M. Iwatsuki, R. Masuma, S. Omura, K. Shiomi. : Virgaricin produced by Virgariasp. FKI-4860. J. Antibiot. 65, 139-141 (2012).

2010

  1. M. Iwatsuki, Y. Kinoshita, M. Niitsuma, J. Hashida, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi, S. Omura. : Anti-trypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporumFKI-4452. J. Antibiot. 63, 331-333 (2010).
  2. H. Gouda, T. Sunazuka, T. Hirose, K. Iguchi, N. Yamaotsu, A. Sugawara, Y. Noguchi, Y. Saito, T. Yamamoto, T. Watanabe, K. Shiomi, S. Omura, S. Hirono. : NMR spectroscopy and computational analysis of interaction between Serratia marcescenschitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin. Bioorg. Med. Chem. 18, 5835-5844 (2010).
  3. S. Ikeda, H. Hanaki, C. Yanagisawa, Y. Ikeda-Dantsuji, H. Matsui, M. Iwatsuki, K. Shiomi, T. Nakae, K. Sunakawa, S. Omura. : Identification of the active component that induces vancomycin resistance in MRSA. J. Antibiot. 63, 533-538 (2010).
  4. J. Hashida, M. Niitsuma, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, H. Ui, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi, S. Omura. : Pyrenocine I, a new pyrenocine analog produced by Paecilomycessp. FKI-3573. J. Antibiot. 63, 559-561 (2010).
  5. M. Niitsuma, J. Hashida, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi, S. Omura. : Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomycessp. K05-0178. J. Antibiot. 63, 673-679 (2010).
  6. M. Iwatsuki, S. Takada, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, K. Shiomi, S. Omura. :In vitroand in vivoantimalarial activities of puberulic acid and its new analogs, viticolins A-C, produced by Penicilliumsp. FKI-4410. J. Antibiot. 64, 183-188 (2011)
  7. K. Kimura, M. Iwatsuki, T. Nagai, A. Matsumoto, Y. Takahashi, K. Shiomi, S. Omura, A. Abe. : A small-molecule inhibitor of the bacterial type III secretion system protects against in vivoinfection with Citrobacter rodentium. J. Antibiot. 64, 197-203 (2011).