micro scope

Laboratory of Microbial Functions

  • Research
  • Members
  • Publications

Research Synopsis

Image from electron microscope

 The number of microorganisms that have been isolated and identified to date is less than 10% of the estimated total number of species in the environment of the earth, and a large number of unknown microorganisms are considered to inhabit nature. We isolate microorganisms from special environments and develop new isolation methods to obtain novel microbial resources useful for drug discovery. We also morphologically and genetically classify isolated microorganisms and evaluate their potential as genetic resources.

 Exploitation of new microbial resources for novel bioactive compounds.

  1. Search for novel microorganisms and their use for material production
  2. Isolation of microorganisms from plants and the elicitation of their latent potentials
  3. Clarification of the morphological differentiation and material production of actinomycetes
New genuses or new kinds of actinomycetes isolated from plant roots
Phytohabitans suffuscus K07-0523T (bar=1µm)
Streptosporangium oxazolinicum K07-0460T (bar=10µm)
  • Laboratory of Microbial Functions


Inahashi Yuki
Inahashi Yuki


  1. Inahashi Y., Matsumoto A., Omura S. and Takahashi Y. ; Phytohabitans flavussp. nov., Phytohabitans rumicis sp. nov. and Phytohabitans houttuyneae sp. nov., isolated from plant roots and emended description of the genus Phytohabitans. Int. J. Syst. Evol. Microbiol. 62:2717-2723 (2012)
  2. Duangmal K., Mingma R., Pathom-aree W., Niyomvon N., Inahashi Y., Matsumoto A., Thamchaipenet A. and Takahashi Y. ; Microbispora thailandensis sp. nov., an actinomycete isolated from cave soil. J Antibiot. 65: 491-494 (2012)
  3. Seki T., Matsumoto A., Shimada R., Inahashi Y., Omura S. and Takahashi Y. ; Conexibacter arvalis sp. nov., isolated from a cultivated field soil sample. Int. J. Syst. Evol. Microbiol. 62:2400-2404 (2012)
  4. Hashida J., Niitsuma M., Iwatsuki M., Mori M, Ishiyama A., Namatame M, Nishihara-Tsukashima A., Matsumoto A., Ara I., Takahashi Y., Yamada H., Otoguro K., Shiomi K. and Omura S. : Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010. J Antibiot. 65: 197-202 (2012)
  5. Koyama R., Matsumoto A., Inahashi Y., Omura S.and Takahashi Y. ; Isolation of actinomycetes from the root of the plant,Ophiopogon japonicus, and proposal of two new species, Actinoallomurus liliacearum sp. nov. and Actinoallomurus vinaceus sp. nov. J Antibiot. 65: 335-340(2012)
  6. Masato I., Nishihara-Tsukashima A., Ishiyama A., Namatame M., Watanabe Y., Handasah S., Oaranamuda H., Marwoto B., Matsumoto A., Takahashi Y., Otoguro K. and Omura S. ; Jagyamycin, a new antiprotozoal aminocyclopentitol antibiotic, produced by Streptomyces sp. a-WM-JG-16.2. J. Antibiot. 65: 169-171(2012)
  7. Matsumoto A., Fukuda A., Inahashi Y., Omura S. and Takahashi Y. ; Actinoallomurus radiciumsp. nov., isolated from the roots of two plant species. Int. J. Syst. Evol. Microbiol. 62: 295-298 (2012)
  8. Aroonsri A., Kitani S., Hashimoto J., Izumikawa M., Komatsu M., Fujita N., Takahashi Y., Shinya K., Ikeda H. and Nihira T. ; Pleiotropiccontrol of secondary metabolism and morphological development by KsbC, a butyrolactone autoregulator receptor homologue in Kitasatospora setae. Appl Environ. Microbiol. 78: 8015-24 (2012)
  9. Nakashima T. Omura S. and Takahashi Y. ; Generation of Superoxide anions by a glycation reaction in conventional laboratory media. J. Biosci. Bioeng. 14: 275-280 (2012)
  10. Nakamichi T., Nakashima T., Takamatsu N., Takahashi Y. and Ishibashi Y. ; Efficient methane fermentation system with hydrolysis technology using high temperature aerobic hydrolysis bacteria. Environ. Safety 3: 13-2 (2012)
  11. 高橋洋子 :「新規生物活性物質探索のための微生物資源の開拓」 Japanese J Antibiot 65: 135-145 (2012)[総説]


  1. K. Duangmal, R. Mingma, W. Pathom-Aree, A. Thamchaipenet, Y. Inahashi, A. Matsumoto and Y. Takahashi : Amycolatopsis samaneae sp. nov., isolated from roots of Samanea saman (Jacq.) Merr. Int. J. Syst. Evol. Microbiol., 61: 951-955 (2011) [IF; 2.133]
  2. K. Duangmal, R. Mingma, W. Pathom-Aree, Y. Inahashi, A. Matsumoto, A. Thamchaipenet and Y. Takahashi : Sphaerisporangium siamense sp. nov., an actinomycete isolated from rubber-tree rhizospheric soil. J. Antibiot. 64: 293-296 (2011) [IF; 1.628]
  3. Y. Inahashi, A. Matsumoto, S. Omura and Y. Takahashi : Streptosporangium oxazolinicum sp. nov., a novel endophytic actinomycete producing new antitrypanosomal antibiotics, spoxazomicins. J. Antibiot. 64: 297-302 (2011) [IF; 1.628]
  4. Y. Inahashi, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, T. Hirose, T. Sunazuka, H. Yamada, K. Otoguro, Y. Takahashi, S. Omura and K. Shiomi : Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T. J. Antibiot. 64: 303-307 (2011) [IF; 1.628]
  5. D. Yamamuro, R. Uchida, Y. Takahashi, M. Masuma and H. Tomoda : Screening for Microbial Metabolite affecting phenotype of Caenorhabditis elagans. Biol. Pharm. Bull. 34. 1619-1623 (2011)
  6. A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, T. Sunazuka, Takahashi Y, S. Omura and K. Otoguro : Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum. J. Antibio. 64: 381-384 (2011) [IF; 1.628]
  7. K. Kimura, M. Iwatsuki, T. Nagai, A. Matsumoto, Y. Takahashi, K. Shiomi, S. Omura and A. Abe : A small-molecule inhibitor of the bacterial type III secretion system protects againstin vivo infection with Citrobacter rodentium. J. Antibiot. 64: 197-203 (2011) [IF; 1.628]
  8. S. Sugimoto, T. Kato, M. Ito, N. Sakata, T. Tsuchida, A. Matsumoto and Y. Takahashi : Branchiibius hedensis gen. nov., sp. nov., an actinobacterium isolated from a Japanese codling ( Physiculus japonicus). Int. J. Syst. Evol. Microbiol., 61: 1195-200 (2011) [IF; 2.113]
  9. C. Indananda, A. Thamchaipenet, A. Matsumoto, K. Duangmal and Y. Takahashi :Actinoallomurus oryzae sp. nov., an endophytic actinomycete isolated from root of Thai jasmine rice plant. Int. J. Syst. Evol. Microbiol., 61: 737-741 (2011) [IF; 2.113]


  1. N. Ichikawa, A. Oguchi, H. Ikeda, J. Ishikawa, S. Kitani, Y. Watanabe, S. Nakamura, Y. Katano, E. Kishi, M. Sasagawa, A. Ankai, S. Fukui, Y. Hashimoto, S. Kamata, M. Otoguro, S. Tanikawa, T. Nihira, S. Horinouchi, Y. Ohnishi, M. Hayakawa, T. Kuzuyama, A. Arisawa, F. Nomoto, H. Miura, Y. Takahashi and N. Fujita : Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae. DNA Res. 17: 393-406 (2010) [IF; 4.917]
  2. M. Niitsuma J. Hashida, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi and S. Omura :Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178. J. Antibiot. 63: 673-679 (2010) [IF; 1.628]
  3. Y. Kobayashi, M. Ichioka, T. Hirose, K. Nagai, A. Matsumoto, H. Matsui, H. Hanaki, R.Masuma, Y.Takahashi, S.Omura and T. Sunazuka : Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorg. Med. Chem. Lett. 20: 6116-6120 (2010) [IF; 2.650]
  4. M. Iwatsuki, K. Otoguro, A. Ishiyama, M. Namatame, A. Nishihara-Tukashima, J. Hashida, T. Nakashima, R. Masuma, Y. Takahashi, H. Yamada and S. Omura : In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships. J. Antibiot. 63: 619-622 (2010) [IF; 1.628]
  5. T. Nakashima, T. Seki, A. Matsumoto, H. Miura, E. Sato, Y. Niwano, M. Kohno, S. Omura and Y. Takahashi : Generation of reactive oxygen species from conventional laboratory media. J. Biosci. Bioeng.., 110: 304-307 (2010) [IF; 1.749]
  6. Y. Inahashi, A. Matsumoto, H. Danbara, S. Omura and Y. Takahashi : Phytohabitans suffuscus gen. nov., sp. nov., an actinomycete of the family Micromonosporaceae isolated from plant roots. Int. J. Syst. Evol. Microbiol., 60: 2652-2658 (2010) [IF; 2.113]
  7. K. Duangmal, R. Mingma, A. Thamchaipenet, A. Matsumoto and Y. Takahashi : Saccharopolyspora phatthalungensis sp. nov., isolated from rhizosphere soil of Hevea brasiliensis. Int. J. Syst. Evol. Microbiol., 60: 1904-1908 (2010) [IF; 2.113]
  8. A. Thamchaipenet, C. Indananda, C. Bunyoo, K. Duangmal, A. Matsumoto and Y. Takahashi : Actinoallomurus acaciae sp. nov., an endophytic actinomycete isolated from Acacia auriculiformis A. Cunn. ex Benth. Int. J. Syst. Evol. Microbiol., 60: 554-559 (2010) [IF; 2.113]
  9. C. Indananda, A. Matsumoto, Y. Inahashi, Y. Takahashi, K Duangmal and A. Thamchaipenet : Actinophytocola oryzaegen. nov., sp. nov., a new member of the family Pseudonocardiaceae isolated from roots of Thai glutinous rice plants. Int. J. Syst. Evol. Microbiol., 60: 1141-1146 (2010) [IF; 2.113]
  10. A. Matsumoto, K. Nakai, K. Morisaki, S. Omura and Y. Takahashi : Demequina salsinemoris sp. nov., isolated by agar media supplemented with ascorbic acid or rutin. Int. J. Syst. Evol. Microbiol., 60: 1206-1209 (2010) [IF; 2.113]
  11. T. Nakamichi, T. Nakashima, H. Fujisaki, N. Takamatsu, T. Muramatsu, Y, Takahashi and Y. Ishibashi : Characteristics of Anoxybacillus sp. MU3 isolated from a hot spring and application to the hyper thermal solubilization of sewage sludge. Environ. Enginee. Science, 27: 993-999(2010) [IF; 1.111]
  12. 高橋洋子:「難培養性放線菌の分類と分類および生物活性物質探索への応用」 IFO Research Communications 24: 31-42 (2010)[総説]