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  4. Drug Discovery Project from Natural Products

Drug Discovery Project from Natural Products

  • Research
  • Members
  • Publications

Research Synopsis

　Primary Objective: Investigation of novel bioactive compounds of microbial origin, including evaluation of their usefulness, as well as the creation of compound libraries.


Key lines of research:

  1. Development of new microbial resources
  2. Creation of new assay systems for screening
  3. Establishment of in vivo systems for bioactivity assays
  4. Investigation of structure/activity relationships
  5. Optimization of biological activity through organic synthesis
  6. Promotion of collaborative research with industry
  7. Maintenance and novel use of compound libraries
Multidiciplinary co-operation in screening for biologically active compounds of microbial origin
  • Satoshi Omura
    Distinguished Emeritus Professor
  • Yukihiro Asami
    Project Associate Professor
  • Yoshihiko Noguchi
    Project Assistant Professor
  • Yoko Suzuki
    Secretary(Research Support)

2012

  1. A. Matsumoto, A. Fukuda, Y. Inahashi, S. Omura and Y. Takahashi. :Actinoallomurus radicium sp. nov., isolated from the roots of two plant species. Int. J. Syst. Evol. Microbiol., 62, 295-298 (2012).
  2. N. Ugaki, D. Matsuda, H. Yamazaki, K. Nonaka, R. Masuma, S. Omura and H. Tomoda. : New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produce by Penicillium sp. FKI-4942: I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot., 65, 15-19 (2012).
  3. A. Ishiyama, K. Otoguro, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, Y. Takahashi, H. Onodera, H. Yamada and S. Omura. :In vitro antitrypanosomal activity of five low-MW antibiotics. J. Antibiot., 65, 113-114 (2012).
  4. K. Otoguro, A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, H. Kiyohara, T. Hashimoto, Y. Asakawa, S. Omura and H. Yamada. : In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei. J. Nat. Med., 66, 377-382 (2012).
  5. T. Ishii, K. Nonaka, M. Iwatsuki, R. Masuma, S. Omura and K. Shiomi. Virgaricin produced by Virgaria sp. FKI-4860. J. Antibiot., 65, 139-141 (2012).
  6. M. Iwatsuki, A. Nishihara-Tsukashima, A. Ishiyama, M. Namatame, Y. Watanabe, S. Handasah, H. Pranamuda, B. Marwoto, A. Matsumoto, Y. Takahashi, K. Otoguro and S. Omura. Jogyamycin, a new antiprotozoal aminocyclopentitol antibiotic, produced by Streptomyces sp. a-WM-JG-16.2. J. Antibiot., 65, 169-171 (2012).
  7. J. Hashida, M. Niitsuma, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, I. Ara, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi and S. Omura. : Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010. J. Antibiot., 65, 197-202 (2012).
  8. R. Koyama, A. Matsumoto, Y. Inahashi, S. Omura and Y. Takahashi. : Isolation of actinomycetes from the root of the plant, Ophiopogon japonicus, and proposal of two new species, Actinoallomurus liliacearum sp. nov. and Actinoallomurus vinaceus sp. nov. J. Antibiot., 65, 335-340 (2012).
  9. H. Gouda, Y. Kobayashi, T. Yamada, T. Ideguchi, A. Sugawara, T. Hirose, S. Omura, T. Sunazuka and S. Hirono. : Three-Dimensional solution structure of bottromycin A2: a potent antibiotic active against meticillin-resistant Staphylococcus aureus and vancomycin- resistant Enterococci. Chem. Pharm. Bull., 60, 169-171 (2012).
  10. M. Ohtawa, K. Sugiyama, T. Hiura, S. Izawa, K. Shiomi, S. Omura and T. Nagamitsu. : Streoslective total synthesis of atpenins A4 andB , harzianopyridone, and NBRI23477B. Chem. Pharm. Bull.,60, 898-906 (2012).
  11. K. Nonaka, H. Miyazaki, M. Iwatsuki, K. Shiomi, H. Tomoda, S. Omura and R. Masuma. : Staphylotrichum boninense, a new hyphomycete(Chaetomiaceae) from soils in the Bonin Islands, Japan. Mycoscience, 53, 312-318 (2012).
  12. T. Nakashima, S. Omura and Y. Takahashi. : Generation of superoxide anions by a glycation reaction in conventional laboratory media. J. Bioscience and Bioengineering,114, 275-280 (2012).
  13. A. Crump, C. M. Morel and S. Omura. : The onchocerciasis chronicle: from the beginning to the end? Trends in Parasitology,28, 280-288 (2012).
  14. T. Yamamoto, N. Izumi, H. Ui, A. Sueki, R. Masuma, K. Nonaka, T. Hirose, T. Sunazuka, T. Nagai, H. Yamada, S. Omura and K. Shiomi. : Wickerols A and B: novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-3849. Tetrahedron, 68, 9267-9271 (2012).
  15. T. Suga, T. Ishii, M. Iwatsuki, T. Yamamoto, K. Nonaka, R. Masuma, H. Matsui, H. Hanaki, S. Omura and K. Shiomi. : Aranorosin Circumvents arbekacin-resistant in MRSA by inhibiting the bifunctional enzyme AAC (6’)/APH(2”). J. Antibiot.,65, 527-529 (2012).
  16. Y. Noguchi, T. Hirose, Y. Furuya, A. Ishiyama, K. Otoguro, S. Omura and T. Sunazuka. : The first total synthesis and reassignment of the relative stereochemistry of 16-hydroxy-16,22-dihydroapparicine. Tetrahedron Letters,53, 1802-1807 (2012).
  17. A. Kimishima, T. Hirose, A. Sugawara, T. Matsumaru, K. Nakamura, K. Katsuyama, M. Toda, H. Takada, R Masuma, S. Omura and T. Sunazuka. : Toward the total synthesis of luminamicin: construction of 14-membered lactones framework possessing versatile enol ether moiety. Tetrahedron Letters,53, 2813-2816 (2012).
  18. S. Kaifuchi, K. Nonaka, M. Mori, K. Shiomi, S. Omura and R. Masuma. : Inducing pigmentation using Hypocrea/Trichoderma co-cultures. Jpn. J. Mycology, 53, 71-81 (2012).
  19. T. Seki, A. Matsumoto, R. Shimada, Y. Inahashi, S. Omura and Y. Takahashi. : Conexibacter arvalis sp. nov., isolated from a cultivated field solid sample. Int. J. System. Evol. Microbiology, 62, 2400-2404 (2012).
  20. Y. Inahashi, A. Matsumoto, S. Omura and Y. Takahashi. : Phytohabitans flavussp. nov., Phytohabitans rumicis sp. nov. and Phytohabitans houttuyneae sp. nov., isolated from plant roots, and emended description of the genus Phytohabitans. Int. J. System. Evol. Microbiology, 62, 2717-2723 (2012).
  21. M. Mominul Houque, K. Suzuki, M. Tsunoda, J. Jiang, F. Zhang, A. Takahashi, N. Ohbayashi, X. Zhang, H. Tanaka, S. Omura and A. Takenaka. : Structural insights into the specific anti-HIV property of actinohivin: structure of its complexwith the a(1-2)mannobiose moiety of gp120. Biol. Crystalography, D68, 1671-1679 (2012).
  22. T. C. Holmes, A. E. May, K. Zaleta-Rivera, J. G. Ruby, P. Skewes-Cox, M. A. Fischbach, J. L. DeRisi, A. Iwatsuki, S. Omura and C. : Khosla. Molecular insights into the biosynthesis of guadinomine: A Type III secretuib system inhibitor. J. Am. Chem. Soc., 134, 17797-17806 (2012).

2011

  1. M. Iwatsuki, S. Takada, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, K. Shiomi, and S. Omura.In vitroand in vivoantimalarial activity of puberulic aci and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410. J. Antibiot., 64, 183-188 (2011).
  2. K. Otsu, H. Ishinaga, S. Suzuki, A. Sugawara, T. Sunazuka, S. Omura, H. Jono, and K. Takeuchi. Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line. Pharmacology,88, 327-332 (2011).
  3. A. Crump and S. Omura. Ivermectin, ‘Wonder drug’ from Japan: the human use perspective. Proc. Jpn. Acads.,Ser. B, 87, 13-28 (2011).
  4. K. Kimura, M. Iwatsuki, T. Nagai, A. Matsumoto, Y. Takahashi, K. Shiomi, S. Omura, and A. Abe. A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacer rodentium. J. Antibiot., 64, 197-203 (2011).
  5. Y. Inahashi, A. Matsumoto, S. Omura, Y. Takahashi.Streptosporangium oxazolinicum sp. nov., a novel endophytic actinomycete producing new antitrypanosomal antibiotics, spoxazomicins. J. Antibiot., 64, 297-302 (2011).
  6. Y. Inahashi, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, T. Hirose, T. Sunazuka, H. Yamada, K. Otoguro, Y. Takashi, S. Omura, and K. Shiomi. Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete,Streptosporangium oxazolinicum K07-0460T. J. Antibiot., 64, 303-307 (2011).
  7. A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, T. Sunazuka, Y. Takahashi, S. Omura, and K. Otoguro. Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures ofPlasmodium falciparum. J. Antibiot., 64, 381-384 (2011).
  8. S. Ohte, D. Matsuda, R. Uchida, K. Nonaka, R. Masuma, S. Omura, and H. Tomoda, Dinapinones, novel inhibitors of triacylglycerol synthesis in mammalian cells, produced by Penicillium pinophilum FKI-3864. J. Antibiot., 64, 489-494 (2011).
  9. A. Takahashi, J. Inokoshi, A. Hachiya, S. Oka, S. Omura, and H. Tanaka. The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity. J.Antibiot.,64, 551-557 (2011).
  10. H. Oguri, T. Hiruma, Y. Yamagishi, H. Oikawa, A. Ishiyama, K. Otoguro, H. Yamada, and S. Omura. Generation of anti-trypanosomal agents through concise synthesis and structural diversification of sesquiterpene analogues. J. Am. Chem. Soc.,133, 7096-7105 (2011).
  11. K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, H. Kiyohara, T. Hashimoto, Y. Asakawa, S. Omura, and H. Yamada.In vitro antitrypanosomal activity of plant terpens against  Trypanosoma brucei. Phytochemistry, 72, 2024-2030 (2011).
  12. S. Kitani, K. T. Miyamoto, S. Takamatsu, E. Herawati, H. Iguchi, K. Nishitomi, M. Uchida, T. Nagamitsu, S. Omura, H. Ikeda, and T. Nihira. Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc. Natl. Acad. Sci., USA, 108, 16410-16415 (2011).
  13. A. Sugawara, A. Sueki, T. Hirose, K. Nagai, H. Gouda, S. Hirono, H. Shima, K. S. Akagawa, S. Omura, and T. Sunazuka. Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 Series as novel leads for anti-inflammatory and/or immunomodulatory agents. Bioorg, & Med. Chem. Lett.,21, 3373-3376 (2011).
  14. T. Miyagawa, K. Nagai, A. Yamada, Y. Sugihara, T. Fukuda, R. Uchida, H. Tomoda, S. Omura, and T. Nagamitsu. Total synthesis of citridone A. Org. Lett.,13, 1158-1161 (2011).
  15. H. Matsui, H. Hanaki, M. Inoue, H. Akama, T. Nakae, K. Sunagawa, and S. Omura. Development of an immiunochromatographic strip for simple detection of Penicillin-binding protein 2’∇. Clin. Vacc. Immunol.,18, 248-253 (2011).
  16. K. Nonaka, R. Masuma, M. Iwatsuki, K. Shiomi, K. Otoguro, and S. Omura. Penicillium viticola, a new species isolated from a grape in Japan. Mycoscience 52, 338-343 (2011).
  17. T. Ohshiro, D. Matsuda, K. Sasaki, C. Degirolamo, H. Yagyu, L. L. Rudel, S. Omura, S. Ishibashi, H. Tomoda. : Pyripyropene A, an acyl-coenzyme A: cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler. Thromb. Vasc. Biol.,3, 1108-1115 (2011).
  18. S. Omura. : Microbial metabolites: 45 years of wandering, wondering and discovering. Tetrahedron,67, 6420-6459 (2011).
  19. T. Shirahata, A. Kojima, S. Teruya, J. Matsuo, M. Yokoyama, S. Unagiike, T. Sunazuka, K. Makino, E. Kaji, S. Omura, and Y. Kobayashi. : Sequential one-pot glycosylation with glycosyl N-trichloroacetylcarbamate and trichloroacetate including dehydrative approach using 1-hydroxy sugars. Tetrahedron,67, 6482-6496 (2011).
  20. M. Mori, H. Morimoto, Y.-P. Kim, H. Ui, K. Nonaka, R. Masuma, K. Sakamoto, K. Kita, H. Tomoda, K. Shiomi, and S. Omura. : Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389. Tetrahedron, 67, 6582-6586 (2011).
  21. T. Hirose, T. Kasai, T. Akimoto, A. Endo, A. Sugawara, K. Nagasawa, K. Shiomi, S. Omura, T. Sunazuka. : Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecycloxy)benzyl tag. Tetrahedron,67, 6633-6643 (2011).
  22. M. Iwatsuki, T. Ishimori, T. Yamamoto, K. Takata, M Mori, K. Nonaka, R. Masuma, Y. Hayakawa, H. Hanaki, K. Shomi and S. Omura. : Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-4429. Tetrahedron, 67, 6644-6648 (2011).
  23. T. Hirose, M. Iwatsuki, S. Omura and T. Sunazuka. : Isolation, total synthesis and determination of the absolute configuration of guadinomines: potent inhibitors of a bacterial type III secretion system. Journal of Synthetic Organic Chemistry, Japan,69, 775-788 (2011).
  24. A. Odani, K. Ishihara, M. Ohtawa, H. Tomoda, S. Omura and T. Nagamitsu. : Total synthesis of pyripyropene A. Tetrahedron,67, 8195-8203 (2011).
  25. K. Nonaka, T. Abe, M. Iwatsuki, M. Mori, T. Yamamoto, K. Shiomi, S. Omura and R. Masuma. : Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655. J. Antibiot. 64, 769-774 (2011).

2010

  1. N. Koyama, S. Kojima, T. Fukuda, T. Nagamitsu, T. Yasuhara, S. Omura and H. Tomoda : Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent. Org. Lett.,12, 432-435 (2010).
  2. J. Inokoshi, Y. Takagi, R. Uchida, R. Masuma, S. Omura and H. Tomoda. : Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942. J. Antibiot., 63, 9-16 (2010).
  3. K. Shiomi, R. Matsui, A. Kakei, Y. Yamaguchi, R. Masuma, H. Hatano, N. Arai, M. Isozaki, H. Tanaka, S. Kobayashi, A. Turberg and S. Omura. : Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. J. Antibiot., 63, 77-82 (2010).
  4. R. Uchida, M. Iwatsuki, Y.-P. Kim, S. Ohte, S. Omura, and H. Tomoda. Nokosomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties. J. Antibiot., 63, 151-155 (2010).
  5. R. Uchida, M. Iwatsuki, Y.-P. Kim, S. Omura, and H. Tomoda.Nokosomycins, new antibiotics discovered in an in vivo mimic infection model using silkworm larve. II: Structure elucidation. J. Antibiot., 63, 157-163 (2010).
  6. N. Koyama, S. Kojima, K. Nonaka, R. Masuma, M. Matsumoto, S. Omura, and H. Tomoda. : Calpinactam, a new anti-mycobacterial agent, produced by Mortierellaalpina FKI-4905. J. Antibiot., 63, 183-186 (2010).
  7. T. Shirahata, J.-I. Matsuo, S. Teruya, N. Hirata, T. Kurimoto, N. Akimoto, T. Sunazuka, E. Kaji, and S. Omura. : Improved catalytic and stereoselective glycosylation with glycosyl N-trichloro-acetylcarbamate: application to various 1-hydroxy sugars. Carbohydrate Re.,345,740-749 (2010).
  8. M. Komatsu, T. Uchiyama, S. Omura, D. E. Cane, and H. Ikeda. : Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc. Natl. Acad. Sci., USA, 107, 2646-2651 (2010).
  9. E. Takashima, H. Yamada, A. Yajima, K. Shiomi, S. Omura, K. Kiyoshi. A quinol peroxidase inhibitor prevents secretion of a leukotoxin from Aggregatibacter actinomycetecomitans. J. Periodont. Res., 45, 123-128 (2010).
  10. T. Hirose, T. Sunazuka, and S. Omura. Recent development of two chitinase inhibitors, argifin and argadin, produced by soil micro- organisms. Proc. Jpn. Acad., Ser.B86, 85-102 (2010).
  11. K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, S. Sato, M. Hatsu, H. Iinuma, S. Shibahara, S. Nimura, S. Kondo, H. Yamada, and S. Omura.In vitro and in vivo antiprotozoal activities of bispolides and their derivatives. J. Antibiot., 63, 275-277 (2010).
  12. H. Yamazaki, S. Omura, and H. Tomoda. Xanthoradone C, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2. J. Antibiot., 63, 329-330 (2010).
  13. M. Iwatsuki, Y. Kinoshita, M. Niitsuma, H.Hashida, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi and S. Omura. Antitrypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporum FKI-4452. J. Antibiot., 63, 331-333 (2010).
  14. K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, S. Shibahara, S. Kondo, H. Yamada and S. Omura. : Promising lead compounds for novel antiprotozoals. J. Antibiot.,63, 381-384 (2010).
  15. M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, H. Ui, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi and S. Omura. : Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573. J. Hashida, M. Niitsuma, M. Iwatsuki, J. Antibiot., 63, 559-561 (2010).
  16. K. Otoguro, A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, T. Nakajima, S. Shibahara, S. Kondo, H. Yamada, and S. Omura. :In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds. J. Antibiot., 63, 579-581 (2010).
  17. M. Iwatsuki, K. Otoguro, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, J. Hashida, T. Nakashima, R. Masuma, Y. Takahashi, H. Yamada and S. Omura. :In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships. J. Antibiot., 63,619-622 (2010).
  18. A. Takahashi, J. Inokoshi, M. Tsunoda, K. Suzuki, A. Takenaka, T. Sekiguchi, S Omura and H. Tanaka. : Actinohivin: specific amino acid residues essential for anti-HIV activity. J. Antibiot.,63, 661-665 (2010).
  19. M. Niitsuma, J. Hashida, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi and S. Omura. : Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178. J. Antibiot., 63, 673-679 (2010).
  20. T. Nakajima, T. Seki, A. Matsumoto, H. Miura, E. Sato, Y. Niwano, M. Kohno, S. Omura and Y. Takahashi. : Generation of reactive oxygen species from conventional laboratory media. J. Biosci. Bioeng.,110, 304-307 (2010).
  21. Y. Kobayashi, M. Ichioka, T. Hirose, K. Nagai, A. Matsumoto, H. Matsui, H. Hanaki, R. Masuma, Y. Takahashi, S. Omura and T. Sunazuka. : Bottromycin derivatives: Efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorg. Med. Chem. Lett.,20, 6116-6120 (2010).
  22. H. Yamazaki, S. Omura and H. Tomoda. 6’-Hydroxy-3’-methoxy-mitorubrin, a new potentiator of antifungal miconazole activity produced by Penicilliim radicum FKI-3765-2. Chem. Pharm. Bull., 58, 829-832 (2010).
  23. H. Gouda, T. Sunazuka, T. Hirose, K. Iguchi, N. Yamaotsu, A. Sugawara, Y. Noguchi, Y. Saito, T. Yamamoto, T. Watanabe, K. Shiomi, S. Omura and S. Hirono. : NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclo-pentapeptide chitinase inhibitor argifin. Bioorg. Med. Chem., 18, 5835-5844 (2010).
  24. T. Nagai, Y. Shimizu, T. Shirahata, T. Sunazuka, H. Kiyohara, S. Omura and H. Yamada. : Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata. Int. Immunopharmacol., 10, 655-661 (2010).
  25. N. Matoba, A. S. Husk, B. W. Barnett, M. M. Pickel, C. J. Arntzan, D. C. Montefiori, A. Takahashi, K Tanno, S. Omura, H. Cao, J. P. Mooney, C. V. Hanson and H. Tanaka. : HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic ativity. PLOS One,5, e11143-1-e11143-13 (2010).
  26. H. Yamazaki, N. Koyama, S. Omura and H. Tomoda. : New rugulosins, anti-MRSA antibiotics, produed by Penicilliuim radicum FKI-3765-2. Org. Lett., 12, 1572-1575 (2010).
  27. A. Matsumoto, K. Nakai, K. Morisaki, S. Omura and Y. Takahashi. :Demequina salsinemoris sp. nov., isolated on agar media supplemented with ascorbic acid or rutin. Int. J. Sys. Evol. Microbiol., 60, 1206-1209 (2010).
  28. Y. Inahashi, A. Matsumoto, H. Danbara, S. Omura and Y. Takahashi. :Phytohabitans suffuscus gen. nov., sp. nov., an actinomycete of the family Micromonosporaceae isolated from plant roots. Int. J. Sys. Evol. Microbiol., 60, 2652-2658 (2010).
  29. H. Namikoshi, T. Sunazuka, Y. Kitamura, T. Suzuki, Y Hamasaki, S. Yamazaki, S. Omura and A. Hatamochi. : Effect of erythromycin A and its new derivative EM201 on type I collagen production by cultured dermal fibroblasts. Arch. Dermatol. Res.,302, 341-348 (2010).
  30. S. Ikeda, H. Hanaki, C. Yanagisawa, Y. Ikeda-Dantsuji, H. Matsui, M. Iwatsuki, K. Shiomi, T. Nakae, K. Sunagawa and S. Omura. : Identification of the active component that induces vancomycin resistance in MRSA. J. Antibiot.,63, 533-538 (2010).