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感染症学研究室

  • 研究の概要
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  • 研究業績

研究の概要

研究の概要

髙橋 孝

 感染症学研究室の理念は、science for society、即ち、社会(一般市民あるいは感染症患者)のための科学を実践することである。その実現のために、研究室と社会あるいは医療施設(大学病院・基幹病院・クリニックなど)との連携を大切にしている。現場から頂いた感染症に関する課題・問題点への対処や解決に結び付くようなヒントを連携者へ提示するよう心掛けている。具体的には、呼吸器感染症・皮膚軟部組織感染症・人獣共通感染症・セプシスといった様々領域の疾患や医療施設内での感染管理に関する研究を行っている。以下に挙げる6項目が主たる研究テーマである。くわえて、国際学生交流(大韓民国・慶尚国立大学医学部と北里生命科学研究所)も実践している。

  1. 侵襲性レンサ球菌感染症の播種性病態生理に関する研究
  2. 呼吸器感染症におけるウイルスと病原細菌との病態関連性の解明
  3. ヘリコバクター属菌感染症における病原性に関する解析
  4. 気道ウイルス感染症に対する新たな治療法の開発
  5. 代謝異常(肥満・糖尿病)下の重症感染症の病態生理に関する研究
  6. 効果的な医療関連感染管理に繋がるエビデンスの確立

研究の概要

松井 英則

  1. ヘリコバクター・ハイルマニイ感染症に関する迅速診断・除菌、感染予防技術の開発
    ハイルマニイの感染診断には、胃生検から調製したDNAに含まれるハイルマニイの16S rRNA遺伝子をPCRで検出する方法が用いられている。しかし、内視鏡による生検は大変である上に、菌が寄生する場所を採取しなければならないという問題がある。そこで、ピロリと同時の感染診断を可能とする、血液・尿(ハイルマニイ抗体の検出)、便(組織化学にも使用可能なハイルマニイVHH抗体の利用)を検体とした迅速検査法を開発している。除菌および感染予防においては、ハイルマニイの薬剤耐性に関わる遺伝子解析、狭域スペクトルの新規抗ヘリコバクター剤の開発、乳酸菌による新たな感染防御システムの開発を行っている。
  2. A群連鎖球菌(group A streptococci, GAS)のM蛋白質の受容体であるヒトCD46を発現するCD46トランスジェニックマウスを用いた、急激な骨破壊機構の解析
    皮膚および軟部組織から感染したGASは、血液に侵入後に骨髄内の血管を破壊し滲出する。線維芽細胞を含む骨髄内の細胞表層のCD46にGASが付着し、その刺激により大量のRANKLが発現する。骨髄中の破骨前駆細胞はRANKLにより活性化破骨細胞に分化し、海綿骨から皮質骨に向かって急激な骨吸収を生じる。従ってRANKL抗体の投与により、誘導される骨吸収は抑制できる。
  3. Salmonella enterica serovar Typhimuriumの感染により誘導される免疫応答の解析
    マウスを用いた感染実験などに最適のサルモネラの野生株や各種遺伝子変異株を提供している。また、遺伝子変異や感染実験の助言も行っている。
レンサ球菌の皮膚から皮下組織血管への想定される侵襲経路
伴侶動物やヒトから分離される溶血性レンサ球菌
GAS皮下感染3日後のCD46 Tgマウス脛骨遠位部切片のTRAP染色
GAS皮下感染3日後のCD46 Tgマウス脛骨遠位部切片のTRAP染色。矢印は活性化した破骨細胞を示す。
bは骨を、bmは骨髄を示す。スケールバーは100 µmを示す。

教職員・大学院学生

教員

髙橋 孝
髙橋 孝
教授(室長)
吉田 春乃
吉田 春乃
助教

大学院生

福島 康仁
福島 康仁
感染制御科学府 博士後期(博士)課程

研究業績

髙橋 孝

平成28 (2016)年度

  1. Fujita T, Horiuchi A, Ogawa M, Yoshida H, Hirose Y, Nagano N, Takahashi T. Genetic diversity in Streptococcus dysgalactiae subsp. equisimilis isolates from patients with invasive and noninvasive infections in a Japanese university hospital (2014-2015). Jpn J Infect Dis. 2017; 70: 100-104.
  2. Taniyama D, Abe Y, Sakai T, Kikuchi T, Takahashi T. Human case of bacteremia caused by Streptococcus canis sequence type 9 harboring the scm gene. IDCases. 2017; 7: 48-52.
  3. Taniyama D, Sakurai M, Sakai T, Kikuchi T, Takahashi T. Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: the first report and literature review. IDCases. 2016; 6: 36-38.
  4. Mori N, Hosoo S, Oyamada Y, Sera Y, Yamada Y, Sugawara M, Higuchi A, Aoki Y, Takahashi T. Characteristics of mucoid Streptococcus pyogenes isolates from two patients with pneumonia in a local community. IDCases. 2016; 6: 43-46.
  5. Matsui H, Nakatani Y, Yoshida H, Takizawa A, Takeuchi O, Overby A, Takahashi T, Murayama SY, Matsuo K. Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-kappaB ligand. Cell Microbiol. 2016; 18: 1390-1404.
  6. Yoshida H, Takahashi T, Nakamura M, Overby A, Takahashi T, Ubukata K, Matsui H. A highly susceptible CD46 transgenic mouse model of subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. J Infect Chemother. 2016; 22: 229-234.
  7. Shibayama A, Yoshizaki T, Tamaki M, Goto M, Takahashi T. Pyogenic sternoclavicular arthritis caused by Streptococcus agalactiae in an elderly patient with diabetes mellitus. J Am Geriatr Soc. 2016; 64: 1376-1377.

平成27 (2015)年度

  1. Takahashi T, Arai K, Lee DH, Koh E, Yoshida H, Yano H, Kaku M, Kim S. Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing. Ann Lab Med. 2016; 36: 9-14.
  2. Ishiki A, Okinaga S, Tomita N, Kawahara R, Tsuji I, Nagatomi R, Taki Y, Takahashi T, Kuzuya M, Morimoto S, Iijima K, Koseki T, Arai H, Furukawa K. Changes in cognitive functions in the elderly living in temporary housing after the Great East Japan Earthquake. PLoS One. 2016; 11: e0147025.
  3. Kajigaya N, Hirose Y, Koike S, Fujita T, Yokota N, Hata S, Ikenaga M, Kobayashi N, Takahashi T. Assessment of contamination using an ATP bioluminescence assay on doorknobs in a university-affiliated hospital in Japan. BMC Res Notes. 2015; 8: 352.
  4. Matsui H, Takahashi T, Overby A, Murayama SY, Yoshida H, Yamamoto Y, Nishiyama K, Seto Y, Takahashi T, Mukai T, Nakamura M. Mouse models for assessing the protective efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis infection associated with the development of gastric mucosa-associated lymphoid tissue lymphoma. Helicobacter. 2015; 20: 291-298.
  5. Yoshida H, Ishigaki Y, Takizawa A, Moro K, Kishi Y, Takahashi T, Matsui H. Comparative genomics of the mucoid and nonmucoid strains of Streptococcus pyogenes, isolated from the same patient with streptococcal meningitis. Genome Announc. 2015; 3: e00221-15.

平成26 (2014)年度

  1. Yamaguchi N, Matsuba K, Okamoto K, Ueyama T, Matsuba Y, Okuzumi K, Watanabe I, Takahashi T. Rodent macrophage selects vin blanc together with vin rouge according to SO level in situ. Open J Rheumatol Autoimmune Dis. 2014; 4: 240-247.
  2. Shibayama A, Tamaki M, Nagasawa H, Nakamata S, Nakamori Y, Yoshida H, Takahashi T. Necrotizing fasciitis caused by infection with Streptococcus pyogenes harboring emm genotype 11 and sequence type 403. J Exp Clin Med. 2014; 6: 166-167.
  3. Kakuta R, Yano H, Hidaka H, Miyazaki H, Irimada M, Oda K, Arai K, Ozawa D, Takahashi T, Kaku M, Katori Y. Severe acute otitis media caused by mucoid Streptococcus pyogenes in a previously healthy adult. Tohoku J Exp Med. 2014; 232: 301-304.
  4. Sugita C, Tanaka S, Takahashi T. Endobronchial cryptococcosis in a non-HIV immunocompromised patient. J Exp Clin Med. 2014; 6: 105-106.
  5. Takahashi T, Iwamoto A. Measles pneumonia: instructive images by chest computed tomography. J Exp Clin Med. 2014; 6: 72-73.
  6. Yamaguchi N, Kawada N, Jia XF, Okamoto K, Okuzumi K, Chen R, Takahashi T. Overall estimation of anti-oxidant activity by mammal macrophage. Open J Rheumatol Autoimmune Dis. 2014; 4: 13-21.
  7. Takahashi T, Iwamoto A. AIDS-related gastric Kaposi’s sarcoma before and after treatment with pegylated liposomal doxorubicin. J Exp Clin Med. 2014; 6: 62-63.
  8. Takahashi T, Okuro M, Iwai K, Morimoto S. A growing mass in the mediastinum: hiatus hernia. J Exp Clin Med. 2014; 6: 64-65.
  9. Takahashi T, Asami R, Inamatsu T. Legionellosis-associated diarrhea: impressive clinical image. J Exp Clin Med. 2014; 6: 39-40.
  10. Makino T, Nagaba Y, Iguchi H, Okada T, Hirose Y, Yokota N, Kajigaya N, Ikenaga M, Takahashi T. Tuberculous iliopsoas abscess: importance of percutaneous intervention under imaging guidance for diagnosis and drainage. J Exp Clin Med. 2014; 6: 31-32.

平成25 (2013)年度

  1. Matoba T, Nakatani Y, Arai K, Matsui H, Yoshida H, Takahashi T. Interleukin-1beta response of peritoneal macrophages to Streptococcus pyogenes exposure: differential response to living and heat-killed bacteria. J Exp Clin Med. 2013; 5: 227-230.
  2. Yamaguchi N, Wan W, Sakamoto D, Nurmuhammad A, Matsumoto K, Takei T, Okuzumi K, Murayama T, Takahashi T. Regulative effect for natural killer cell by hot spring hydrotherapy-quantitative and qualitative discussion. Open J Immunol. 2013; 3: 201-209.
  3. Takahashi T, Iwamoto A. Perianal fistula caused by intestinal invasive amebiasis in a male patient with AIDS. J Exp Clin Med. 2013; 5: 237-238.
  4. Sadanari H, Murayama T, Zheng X, Yamada R, Matsubara K, Yoshida H, Takahashi T. Inhibitory effects of statins on expression of immediate-early 1 protein of human cytomegalovirus in virus-infected cells. J Exp Clin Med. 2013; 5: 187-193.
  5. Takano F, Bi C, Ishigaki Y, Yoshida H, Sakurada C, Takahashi T. Anticholesteremic agents, statins, modulate monocyte activation in cultured human THP-1 cells. Pharmacometrics. 2013; 84: 75-81.
  6. Ogawa M, Iguchi H, Taoka Y, Yamazaki H, Hirose Y, Yokota N, Kajigaya N, Ikenaga M, Takahashi T. Perirenal and renal abscesses: assessment by multiplanar reformat imaging of computed tomography. J Exp Clin Med. 2013; 5: 120-121.
  7. Takei T, Morozumi M, Ozaki H, Fujita H, Ubukata K, Kobayashi I, Kadota K, Miyamae T, Yokota S, Iwata S, Takahashi T. Clinical features of Mycoplasma pneumoniae infections in the 2010 epidemic season: report of two cases with unusual presentations. Pediatr Neonatol. 2013; 54: 402-405.
  8. Takei T, Chiba N, Fujita H, Morozumi M, Kuwata Y, Kishii K, Ubukata K, Iwata S, Takahashi T. Late onset invasive group B streptococcal infection with serotype VIII in a neonate having congenital biliary atresia. Pediatr Neonatol. 2013; 54: 63-66.

平成24 (2012)年度

  1. Takahashi T, Goto M, Yoshida H, Sumino H, Matsui H. : Infectious diseases after the 2011 Great East Japan Earthquake. J Exp Clin Med. 2012; 4: 20-23.
  2. Murayama T, Li Y, Takahashi T, Yamada R, Matsubara K, Tsuchida Y, Zheng X, Sadanari H. : Anti-cytomegalovirus effects of tricin are dependent on CXCL11. Microbes Infect. 2012; 14: 1086-1092.
  3. Okada T, Morozumi M, Sakata H, Takayanagi R, Ishiwada N, Sato Y, Oishi T, Tajima T, Haruta T, Kawamura N, Ouchi K, Matsubara K, Chiba N, Takahashi T, Iwata S, Ubukata K. : A practical approach estimating etiologic agents using real-time PCR in pediatric inpatients with community-acquired pneumonia. J Infect Chemother. 2012; 18: 832-840.
  4. Ishikawa K, Kanazawa Y, Morimoto S, Takahashi T. : Depopulation with rapid aging in Minamisoma city after the Fukushima Daiichi nuclear power plant accident. J Am Geriatr Soc. 2012; 60: 2357-2358.

平成23 (2011)年度

  1. Hasegawa M, Okada T, Sakata H, Nakayama E, Fuchigami T, Inamo Y, Mugishima H, Tajima T, Iwata S, Morozumi M, Ubukata K, Watanabe H, Takahashi T. : Pandemic (H1N1) 2009-associated pneumonia in children, Japan. Emerg Infect Dis. 2011; 17: 277-280.
  2. Yoshida H, Matsui H, Murayama SY, Takada Y, Matsuo K, Takahashi T, Nakamura M, Ubukata K, Takahashi T. : A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis (SDSE). J Med Microbiol. 2011; 60: 1860-1868.
  3. Takahashi T, Ubukata K, Watanabe H :. Invasive infection caused by Streptococcus dysgalactiae subsp. equisimilis: characteristics of strains and clinical features. J Infect Chemother. 2011; 17: 1-10.
  4. Takahashi T, Iijima K, Kuzuya M, Hattori H, Yokono K, Morimoto S. : Guidelines for non-medical care providers to manage the first steps of emergency triage of elderly evacuees. Geriatr Gerontol Int. 2011; 11: 383-394.

平成22 (2010)年度

  1. Takahashi T, Sunaoshi K, Sunakawa K, Fujishima S, Watanabe H, Ubukata K, and the Invasive Streptococcal Disease Working Group. : Clinical aspects of invasive infections with Streptococcus dysgalactiae subsp. equisimilis in Japan: differences with respect to Streptococcus pyogenes and Streptococcus agalactiae. Clin Microbiol Infect. 2010; 16: 1097-1103.
  2. Hasegawa M, Inamo Y, Fuchigami T, Hashimoto K, Morozumi M, Ubukata K, Watanabe H, Takahashi T. : Bronchial casts and pandemic (H1N1) 2009 virus infection. Emerg Infect Dis. 2010; 16: 344-346.
  3. Hasegawa M, Hashimoto K, Morozumi M, Ubukata K, Takahashi T, Inamo Y. : Spontaneous pneumomediastinum complicating pneumonia in children infected with the 2009 pandemic influenza A (H1N1) virus. Clin Microbiol Infect. 2010; 16: 195-199.
  4. Matsui H, Sekiya Y, Aikawa C, Murayama SY, Takahashi T, Yoshida H, Takahashi T, Tsuchimoto K, Nakamura M. : Candidatus Helicobacter heilmannii infection in the course of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in human beings and mouse models. Curr Trends Microbiol. 2010; 6: 27-34.

松井 英則(*Corresponding author)

平成29 (2017)年度

  1. 松井英則*, 高橋哲史, 村山琮明, 川口満里奈, 松尾光一, 中村正彦. 乳酸菌が産生する不飽和脂肪酸の抗ヘリコバクター属活性.日本ヘリコバクター学会誌, 19 (2), 2018. in press. Award Report 上原H.pylori賞-優秀賞-
  2. Flahou B.*, Nakamura M., Matsui H., Haesebrouck F.(他29名) Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs. ISME J., Sep 08. doi: 10.1038/ismej.2017.145 (Epub date: 2017/09/09), 2017.
  3. Matsui H.*, Takahashi T., Murayama S.Y., Kawaguchi M., Matsuo K., Nakamura M. Protective efficacy of a hydroxyl fatty acid against gastric Helicobacter infections. Helicobacter, 22(4), e12430, 2017.
  4. 松井英則*, 高橋哲史, 中村正彦, 動物実験におけるマイクロバイオームの知見とHelicobacter属感染. Helicobacter Research 21 (3) 65 (251)-69 (255), 2017.
  5. Nakamura M.*, Øverby A., Matsui M. Angiogenesis and lymphangiogenesis in gastric MALT lymphoma: Relation of VEGF and VASH2: Novel therapies for digestive diseases. in Therapeutic targets for inflammation and cancer. Chi Hin Cho (ed.), pp. 177-188., World Scientific. 460 pages doi: 10.1142/9789813148574_0008, 2017.
  6. Nakamura M.*, Øverby A., Uehara A., Oda M., Takahashi S., Murayama S.Y., Matsui H. Significance of cholinergic and peptidergic nerves in stress-induced ulcer and MALT lymphoma formation. Curr. Pharm. Des., 23 (27), 3933-3996, 2017.

平成28 (2016)年度

  1. Matsui H.*, Takahashi T., Murayama S.Y., Uchiyama I., Yamaguchi K., Shigenobu S., Suzuki M., Rimbara E., Shibayama K., Øverby A., Nakamura M. Draft genome sequence of Helicobacter suis strain SNTW101, isolated from a Japanese patient with nodular gastritis. Genome Announc., 4 (5), e00934-16, 2016.
  2. Matsui H.*, Nakatani Y., Yoshida H., Takizawa A., Takeuchi O., Øverby A., Takahashi T., Murayama S.Y., Matsuo K. Fresh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-kB ligand. Cell. Microbiol., 18 (10), 1390-1404, 2016.
  3. Yamamoto T., Matsui H.*, Yamaji K., Takahashi T., Øverby A., Nakamura M., Matsumoto A., Nonaka K., Sunazuka T., ?mura S., Nakano H. Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. J. Infect. Chemother., 22 (9), 587-592, 2016.
  4. Yoshida H., Takahashi T., Nakamura M., Øverby A., Takahashi T., Ubukata K., Matsui H.* A highly susceptible CD46 transgenic mouse model of subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. J. Infect. Chemother., 22 (4), 229-234, 2016.
  5. Kuroda K., Maruyama K., Fujii H., Sugawara I., Ko S.B.H., Yasuda H., Matsui H., Matsuo K.* Osteoprotegerin regulates pancreatic ß-cell homeostasis upon microbial invasion. PLoS ONE, 11 (1), e0146544, 2016.
  6. Aribam S.D., Harada T., Eisheimer-Matulova M., Iwata T., Kanehisa K., Hikono H., Matsui H., Ogawa Y., Shimoji Y. Eguchi M.* Specific monoclonal antibody overcomes the Salmonella enterica serovar Typhimurium’s adaptive mechanisms of intramacrophage survival and replication. PLoS ONE, 11 (3), e0151352, 2016.
  7. 中村正彦*, Anders Øverby, 高橋哲史, 松井英則, 高橋信一, 村山琮明.(トピックス)ピロリ菌陰性でも要注意!? 広義のハイルマニイ菌(Helicobacter heilmannii), 検査と技術 44 (4), 278-284, 2016.
  8. Øverby A., Murayama S.Y., Matsui H., Nakamura M.* In the aftermath of Helicobacter pylori: other helicobacters rising up to become the next gastric epidemic?  Digestion, 93 (4), 260-265, 2016.
  9. Nakamura M.*, Øverby A., Murayama S.Y., Suzuki H., Takahashi T., Takahashi S., Matsui H. Gastric non-Helicobacter pylori Helicobacter: Its significance in human gastric disease. Springer, Suzuki H., Warren R., Marshall B. (eds), Helicobacter pylori, pp. 131-140., ISBN 978-4-431-55704-3, 329854_1, 2016.

平成27 (2015)年度

  1. Yoshida H., Ishigaki Y., Takizawa A., Moro K., Kishi Y., Takahashi, T., Matsui H.* Comparative genomics of mucoid and nonmucoid strains of Streptococcus pyogenes isolated from the same patient with streptococcal meningitis. Genome Announc., 3 (2), e00221-15, 2015.
  2. Matsui H.*, Takahashi T., Øverby A., Murayama S.Y., Yoshida H., Yamamoto Y., Nishiyama K., Seto Y., Takahashi T., Mukai T., Nakamura M. Mouse models for assessing the protective efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis infection associated with the development of gastric mucosa-associated lymphoid tissue lymphoma. Helicobacter, 20 (4), 291-298, 2015.
  3. Matsui H.*, Fukiya S., Kodama-Akahoshi C., Eguchi M., Yamamoto T. Mouse models for assessing the cross-protective efficacy of oral non-typhoidal Salmonella vaccine candidates harboring in-frame deletions of the ATP-dependent protease lon and other genes. J. Med. Microbiol., 64 (Pt 3), 295-302, 2015.
  4. Matsui H.*, Isshiki Y., Eguchi M., Ogawa Y., Shimoji Y. Evaluation of the live vaccine efficacy of virulence plasmid-cured, and phoP- or aroA- deficient Salmonella enterica serovar Typhimurium in mice. J. Vet. Med. Sci., 77 (2), 181-186, 2015.
  5. Yang L., Yamamoto K., Nishiumi S., Nakamura M., Matsui H., Takahashi S., Dohi T., Okada T., Kakimoto K., Hoshi N., Yoshida M.*, Azuma T. Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection. Muc. Immunol., 8 (2), 279-295, 2015.
  6. Aribam S.D., Ogawa Y., Matsui H., Hirota J., Okamura M., Akiba M., Shimoji Y., Eguchi M.* Monoclonal antibody-based competitive enzyme-1 linked immunosorbent assay to detect antibodies to O:4 Salmonella in the sera of livestock and poultry. J. Microbiol. Methods, 108, 1-3, 2015.
  7. Aribam S.D., Elshemer-Matulova M., Matsui H., Hirota J., Shiraiwa K., Ogawa Y., Hikono H., Shimoji Y., Eguchi M.* Variation in antigen-antibody affinity among serotype of Salmonella )4 serogroup, determined using specific antisera. FEMS Microbiol. Lett., 362 (21), fnv168, 2015.
  8. Sasaki, M.*, Goji, S., Tamura, Y., Nakamura, M., Matsui, H., Murayama, S.Y., Ebi, M., Ogasawara, N., Funai, Y., Kasugai, K. Helicobacter suis-infected nodular gastritis and a review of diagnostic sensitivity for Helicobacter heilmannii-like organisms. Case Rep. Gastroenterol., 9, 179-187, 2015.
  9. 中村正彦*, 高橋哲史, 松井英則, 高橋信一, 村山琮明, 土本寛二.もうひとつの胃内のHelicobacter属細菌 HHLO, H. heilmannii, H. suis —その発見史、特徴、診断、治療についてー. 日本ヘリコバクター学会誌, 15, 45-52, 2015.

平成26 (2014)年度

  1. Matsui H.*, Takahashi T., Murayama S.Y., Uchiyama I., Yamaguchi K., Shigenobu S., Matumoto T.,Kawakubo M., Horiuchi K., Ota H., Osaki T., Kamiya S., Smet A., Flahou B., Ducatella R., Haesebrouck F., Takahashi S., Nakamura S., Nakamura M. Development of new PCR primers by comparative genomics for the detection of Helicobacter suis in gastric biopsy specimens. Helicobacter, 19 (4), 260-271, 2014. 抄訳版出版
  2. Yamamoto K., Yang Y., Nishium S., Nakamura M. , Matsui H., Takahashi S., Dohi T., Okada T., Kakimoto K., Yoshida M.*, Azuma T., Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection. Muc. Immunol., 7 (5), 1244-1254, 2014.
  3. Uchida R., Hanaki H., Matsui H., Hamamoto H., Sekimizu K., Iwatsuki M., Kim Y.P., Tomoda H.* In vitro and in vivo anti-MRSA activities of nosokomycins. Drug. Discov. Ther., 8 (6), 249-254, 2014.
  4. 松井英則*. ヘリコバクター・ピロリ (Helicobacter pylori), 微生物検査イエローページ 臨床検査増刊号, 58 (11), 1353-1356, 2014.
  5. 松井英則*, 高橋哲史, 中村正彦. Helicobacter suis感染とMALTリンパ腫. 無菌生物, 44 (1), 47-50, 2014.
  6. Nakamura M.*, Takahashi T., Matsui H., Baniwa Y., Takahashi S., Murayama S.Y., Serizawa H., Suzuki H., Hibi T. Alteration of angiogenesis in Helicobacter heilmannii-induced mucosa-associated lymphoid tissue lymphoma: Interaction with c-Met and hepatocyte growth factor. J. Gastroenterol. Hepatol.,29 Suppl 4:70–76, 2014.
  7. Nakamura M.*, Takahashi T., Matsui H., Takahashi S., Murayama S.Y., Suzuki H, Tsuchimoto K. New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib. Curr. Pharm. Des., 20, 1097-1103, 2014.