北里大学海洋生命科学部

北里大学海洋生命科学部

学校法人 北里研究所

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教員プロフィール 筒井 繁行

トップ 教育・研究 教員組織教員プロフィール 筒井 繁行

 

氏名 筒井 繁行(Shigeyuki Tsutsui) 筒井 繁行講師(水族病理学研究室)
所属 水族病理学研究室
職位 准教授
略歴

1991年 盛岡第一高等学校卒業
1998年 東京大学農学部水圏生物科学専攻修了
2001年 東京大学大学院農学生命科学科修士課程修了 修士(農学)
2004年 東京大学大学院農学生命科学科博士課程修了 博士(農学)
2004年 東京大学農学特定研究員
2005年 北里大学水産学部 助手
2007年 北里大学水産学部 助教
2007年 北里大学水産学部 講師
2008年 北里大学海洋生命科学部 講師(学部名称の変更)
2018年 北里大学海洋生命科学部 准教授

研究テーマ 魚類および円口類の免疫に関する研究(特に体表における防御機構)
主要業績 Igarashi K, Matsunaga R, Hirakawa S, Hosoya S, Suetake H, Kikuchi K, Suzuki Y, Nakamura O, Miyadai T, Tasumi S, Tsutsui S. (2017) Mucosal IgM antibody with D-mannose affinity in fugu Takifugu rubripes is utilized by a monogenean parasite Heterobothrium okamotoi for host recognition. J. Immunol. 198(10):4107-4114.

Taguchi M, Tsutsui S, Nakamura O. (2016) Differential count and time-course analysis of the cellular composition of coelomocyte aggregate of the Japanese sea cucumber Apostichopus japonicus. Fish Shellfish Immunol. 58:203-209.

Tsutsui S, Yoshinaga T, Komiya K, Yamashita H, Nakamura O. (2016). Differential expression of skin mucus C-type lectin in two freshwater eel species, Anguilla marmorata and Anguilla japonica. Dev Comp Immunol. 26;61:154-160.

Tasumi S, Yamaguchi A, Matsunaga R, Fukushi K, Suzuki Y, Nakamura O, Kikuchi K, Tsutsui S. (2016). Identification and characterization of pufflectin from the grass pufferfish Takifugu niphobles and comparison of its expression with that of Takifugu rubripes. Dev Comp Immunol. 59:48-56.

Ueda K, Saito E, Iwasaki K, Tsutsui S, Nozawa A, Kikuchi K, Nakamura O. (2016). Accumulation of cells expressing macrophage colony-stimulating factor receptor gene in the ovary of a pregnant viviparous fish, Neoditrema ransonnetii (Perciformes, Embiotocidae). Fish Shellfish Immunol. 50:223-230.

Tsutsui S, Yoshinaga T, Watanabe S, Aoyama J, Tsukamoto K, Nakamura O. (2015). Skin mucus C-type lectin genes from all 19 Anguilla species/subspecies. Fish. Sci. 81:1043-1051.

Tsutsui S, Yamamura N, Yoshida T, Nakamura O. (2015). Fugu (Takifugu rubripes) serum GlcNAc-binding lectin is a kalliklectin but has different properties from those of a reported homologue. J Biochem. 158(3):189-195.

Tsutsui S, Dotsuta Y, Ono A, Suzuki M, Tateno H, Hirabayashi J, Nakamura O. (2015). A C-type lectin isolated from the skin of Japanese bullhead shark (Heterodontus japonicus) binds a remarkably broad range of sugars and induces blood coagulation. J Biochem. 157(5):345-356.

Nakamura O, Watabe Y, Matsumoto N, Takasugi O, Watanabe A, Tsutsui S. (2014). Localization and possible function of nrF-AGP, an alpha-1-acid glycoprotein-like protein in viviparous fish Neoditrema ransonnetii (Perciformes, Embiotocidae). Fish Physiol Biochem. 40(6):1907-1915.

Tsutsui S, Ariji T, Sato A, Yoshida T, Yamamura N, Odaka T, Araki K, Suetake H, Miyadai T, Nakamura O. (2013). Serum GlcNAc-binding IgM of fugu (Takifugu rubripes) suppresses the growth of fish pathogenic bacteria: A novel function of teleost antibody. Dev Comp Immunol. 41(1):20-26.

Nakamura O, Watanabe M, Ogawa T, Muramoto K, Ogawa K, Tsutsui S, Kamiya H. (2012). Galectins in the abdominal cavity of the conger eel Conger myriaster participate in the cellular encapsulation of parasitic nematodes by host cells. Fish Shellfish Immunol. 33(4):780-787.

Tsutsui S, Komatsu Y, Sugiura T, Araki K, Nakamura O. (2011). A unique epidermal mucus lectin identified from catfish (Silurus asotus): First evidence of intelectin in fish skin slime. J Biochem. 150(5):501-514.

Tsutsui S, Okamoto M, Ono M, Suetake H, Kikuchi K, Nakamura O, Suzuki Y, Watanabe T. (2011). A new type of lectin discovered in a fish, flathead (Platycephalus indicus), suggests an alternative functional role for mammalian plasma kallikrein. Glycobiology. 21(12):1580-1587.

Odaka T, Tsutsui S, Sugamata R, Suetake H, Miyadai T, Suzuki Y, Watanabe T, Nakamura O. (2011). The plasmablast-like leukocyte in the kidney of fugu (Takifugu rubripes). Fish Shellfish Immunol. 30(2):682-690.

Tsutsui S, Yamaguchi M, Hirasawa A, Nakamura O, Watanabe T (2009) Common skate (Raja kenojei) secrets pentraxin into the cutaneous secretion: The first skin mucus lectin in cartilaginous fish. J. Biochem. 146: 295-306.

Nakamura O, Wada Y, Namai F, Saito E, Araki K, Yamamoto A, Tsutsui S. A novel C1q family member with fucose-binding activity from surfperch, Neoditrema ransonnetii (Perciformes, Embiotocidae). Fish Shellfish Immunol. 27: 714-720.

Nakamura O, Nozawa Y, Saito E, Ikeda D, Tsutsui S (2009) Suppression of lymphocyte proliferation by ovarian cavity fluid from the viviparous fish Neoditrema ransonnetii (Perciformes; Embiotocidae). Fish Shellfish Immunol. 27: 549-555.

Komatsu K, Tsutsui S, Hino K, Araki K, Yoshiura Y, Yamamoto A, Nakamura O, Watanabe T (2009) Expression profiles of cytokines released in intestinal epithelial cells of the rainbow trout, Oncorhynchus mykiss, in response to bacterial infection. Dev. Comp. Immunol. 33: 499-506.

Nakamura O, Nozawa Y, Saito E, Ikeda D, Tsutsui S. An alpha-1-acid glycoprotein-like protein as a major component of the ovarian cavity fluid of viviparous fish, Neoditrema ransonnetii (Perciformes, Embiotocidae). Comp. Biochem. Physiol. A . 153: 222-229.

Tsutsui S, Yoshino Y, Matsui S, Nakamura O, Muramoto K, Watanabe T (2008) Isolation of epidermal cells and cDNA cloning of TNF decoy receptor 3 of conger eel, Conger myriaster. Fish Shellfish Immunol. 24: 366-371.

Tsutsui S, Nakamura O, Watanabe T (2007) Lamprey (Lethenteron japonicum) IL-17 upregulated by LPS-stimulation in the skin cells. Immunogenetics 59: 873-882.

Tsutsui S, Iwamoto T, Nakamura O, Watanabe T (2007) LPS induces gene expression of interleukin-1β in conger eel (Conger myriaster) macrophages: First cytokine sequence within Anguilliformes. Fish Shellfish Immunol. 23: 911-916.

Nakamura O, Inaga Y, Suzuki S, Tsutsui S, Muramoto K, Kamiya H, Watanabe T (2007) Possible immune functions of congerin, a mucosal galectin, in the intestinal lumen of Japanese conger eel. Fish Shellfish Immunol. 23: 683-692.

Tsutsui S, Iwamoto K, Nakamura O, Watanabe T (2007) Yeast-binding C-type lectin with opsonic activity from conger eel (Conger myriaster) skin mucus. Mol. Immunol. 44: 691-702.

Tsutsui S, Nishikawa H, Mano N, Hirose H, Tasumi S, Suetake H, Suzuki Y (2006). Possible role of a skin mucus lectin from fugu (Takifugu rubripes) in excluding marine bacteria from the body surface. Fish. Sci. 72: 455-457.

Tsutsui S, Tasumi S, Suetake H, Kikuchi K, Suzuki Y (2006) Carbohydrate-binding site of a novel mannose-specific lectin from fugu (Takifugu rubripes) skin mucus. Comp. Biochem. Physiol. B 143: 514-519.

Tsutsui S, Okamoto M, Tasumi S, Suetake H, Kikuchi K, Suzuki Y (2006) Novel mannose-specific lectins found in torafugu, Takifugu rubripes: A review. Comp. Biochem. Physiol. 1: 122-127.

Okamoto M, Tsutsui S, Tasumi S, Suetake H, Kikuchi K, Suzuki Y (2005) Tandem repeat L-rhamnose-binding lectin from the skin mucus of ponyfish, Leiognathus nuchalis. Biochemi. Biophys. Res. Commun. 333: 463-469.

Tsutsui S, Tasumi S, Suetake H, Kikuchi K, Suzuki Y (2005) Demonstration of the mucosal lectins in the epithelial cells of internal and external body surface tissues in pufferfish (Fugu rubripes). Dev. Comp. Immunol. 29: 243-253.

Tasumi S, Yang WJ, Usami T, Tsutsui S, Ohira T, Kawazoe I, Wilder MN, Aida K, Suzuki Y (2004) Characteristics and primary structure of a galectin in the skin mucus of the Japanese eel, Anguilla japonica. Dev. Comp. Immunol. 28: 325-335.

Suzuki Y, Tasumi S, Tsutsui S, Okamoto M, Suetake H (2003) Molecular diversity of skin mucus lectins in fish. Comp. Biochem. Physiol. B 136: 723-730.

Tsutsui S, Tasumi S, Suetake H, Suzuki, Y (2003) Lectins homologous to those of monocotyledonous plants in the skin mucus and intestine of pufferfish, Fugu rubripes. J. Biol. Chem. 278: 20882-20889.

Tsutsui S, Tanaka M, Miyazaki N, Furuya T (2001) Pacific white-sided dolphins (Lagenorhynchus obliquidens) with anomalous color patterns in Volcano Bay, Hokkaido, Japan. Aquatic Mammals 27 172-182.

その他 【科学研究費補助金(代表)】
・基盤研究 (C):ゲノム編集技術を用いた寄生虫フリーのトラフグの作出 (2017-2019年).
・基盤研究 (C):トラフグ寄生虫の着定メカニズムの解明とその駆除 (2014-2016年).
・若手研究 (B): 無顎類表皮の細胞における防御機構 (2012-2013年).
・若手研究 (B): 魚類体表防御因子のプロテオーム解析 (2009-2010年).
・若手研究 (スタートアップ): 無顎類および魚類の皮膚における防御機構(2006-2007年).

【受賞】
・日本水産学会 水産学奨励賞 (2011年度).
・Award to Student Poster Competition, 9th Congress of the International Society for Developmental & Comparative Immunology (国際比較免疫学会ポスター賞) (2003).