RESEARCH
免疫学
キーワード:#リンパ球 #細胞傷害 #細胞分化
リンパ球による免疫反応制御の仕組みを解明する
病原体の侵入やがんに対する免疫システムの制御機構についてはまだわからないことが多く残されています。
私たちの研究室では、がんや病原体に対する免疫反応の実体とそれがどのように制御されているのか研究を行っています。こうした研究を通じ、感染症、免疫性疾患、アレルギーやがんの問題に立ち向かっていきたいと考えています。
業績
Group2 innate lymphoid cells ameliorate renal fibrosis and dysfunction associated with adenine-induced CKD.
Ryuichi Nagashima, Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Koji Eshima, Masayuki Iyoda.
Cell Immunol, 401-402 (2024 Jul-Aug) :104828 (2024)
doi: 10.1016/j.cellimm.2024.104828
Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice.
Hiroki Ishikawa, Ryuichi Nagashima, Yoshihiro Kuno, Hiraku Sasaki, Chikara Kohda, Masayuki Iyoda.
Diabetes, metabolic syndrome and obesity : targets and therapy, 16 :2855-2864 (2023)
doi: 10.2147/DMSO.S428190
The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells.
Amano H, Eshima K, Ito Y, Nakamura M, Kitasato H, Ogawa F, Hosono K, Iwabuchi K, Uematsu S, Akira S, Narumiya S, Majima M..
Cardiovascular Research, 119 (5) :1218-1233 (2023)
doi: 10.1093/cvr/cvac137
HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages.
Ryuichi Nagashima, Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Masayuki Iyoda.
Scientific reports, 13 (1) :1867 (2023)
doi: 10.1038/s41598-023-29161-3
Intravenous immunoglobulin preparations attenuate lysolecithin-induced peripheral demyelination in mice and comprise anti-large myelin protein zero antibody
Setoguchi, Y., Hayashi, A., Kawada, A., Ibusuki, A., Yanaoka, D., Saito, R., Ishibashi, T., Takimoto, H., Yamaguchi, Y., Ohtaki, H., Baba, H..
Proc Jpn Acad Ser B Phys Biol Sci, 99 (2) :48-60 (2023)
https://www.ncbi.nlm.nih.gov/pubmed/36775342
Oral supplementation of a cell preparation of Enterococcus faecalis strain EC-12 stimulates superoxide dismutase production in the livers of healthy and arthritis-induced mice
Tsukahara, T., Makioka-Itaya, Y., Takimoto, H., Ijichi, T..
J Clin Biochem Nutr, 72 (1) :39-45 (2023)
https://www.ncbi.nlm.nih.gov/pubmed/36777079
Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration.
Mishima K, Okabe YT, Mizuno M, Ohno K, Kitoh H, Imagama S..
Scientific Reports, 12 (1) :20550 (2022)
https://pubmed.ncbi.nlm.nih.gov/36446942/
doi: 10.1038/s41598-022-25184-4.
IL-33 attenuates renal fibrosis via group2 innate lymphoid cells.
Ryuichi Nagashima, Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Masayuki Iyoda.
Cytokine, 157 :155963 (2022)
doi: 10.1016/j.cyto.2022.155963.
Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 prevent influenza virus infection and attenuate secondary bacterial infection risk.
Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Hiraku Sasaki, Ryuichi Nagashima, Masayuki Iyoda.
Letters in applied microbiology, 74 (5) :632-639 (2022)
doi: 10.1111/lam.13649
The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis.
Ryuichi Nagashima, Masayuki Iyoda.
Frontiers in immunology, 12 :688647 (2021)
doi: 10.3389/fimmu.2021.688647
Efficient immunogenic peptide antigen delivery to dendritic cells using an ESCRT-mediated extracellular vesicle formation method.
Sakika Kimura, Koki Maeda, Ryuichi Nagashima, Koya Miura, Masashi Arakawa, Hirotaka Ebina, Nobuyuki Tanaka, Eiji Morita.
Vaccine, 39 (22) :2976-2982 (2021)
doi: 10.1016/j.vaccine.2021.04.021.
Natural killer cell group 7 sequence in cytotoxic cells optimizes exocytosis of lytic granules essential for the Perforin-dependent, but not FasL-dependent cytolytic pathway.
Morikawa Y, Murakami M, Kondo H, Nemoto N, Iwabuchi K, Eshima K*..
ImmunoHorizons, 5 (4) :234-345 (2021)
doi: 10.4049/immunohorizons.2100029
Biological characterization of adipose-derived regenerative cells used for the treatment of stress urinary incontinence.
Okabe YT, Shimizu S, Suetake Y, Matsui-Hirai H, Hasegawa S, Takanari K, Toriyama K, Kamei Y, Yamamoto T, Mizuno M, Gotoh M..
International Journal of Urology, 28 (1) :115-124 (2021)
https://pubmed.ncbi.nlm.nih.gov/33289131/
doi: 10.1111/iju.14408.
NF-κB-inducing kinase contributes to normal development of cortical thymic epithelial cells: its possible role in shaping a proper T-cell repertoire.
Eshima K, Misawa K, Ohashi C, Noma H, Iwabuchi K..
Immunology, 160 (2) :198-208 (2020)
doi: 10.1111/imm.13186
Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells.
Makoto Kubo, Ryuichi Nagashima, Mitsue Kurihara, Fumitaka Kawakami, Tatsunori Maekawa, Koji Eshima, Etsuro Ohta, Hirotomo Kato, Fumiya Obata.
International journal of molecular sciences , 21 (5) :1890 (2020)
doi: 10.3390/ijms21051890.
A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats.
Kitase Y, Sato Y, Ueda K, Suzuki T, Mikrogeorgiou A, Sugiyama Y, Matsubara K, Tsukagoshi Okabe Y, Shimizu S, Hirata H, Yukawa H, Baba Y, Tsuji M, Takahashi Y, Yamamoto A, Hayakawa M..
Stem Cells and Development, 29 (2) :63-74 (2020)
https://doi.org/10.1089/scd.2019.0221
doi.org/10.1089/scd.2019.0221
Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.
Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Tsukagoshi Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M.
Nature communications, 10 (1) :4262 (2019)
doi.org/10.1038/s41467-019-12282-7
Invasion of human microvascular endothelial cells by Mycobacterium leprae through Mce1A protein
Idris, I., Abdurrahman, A. H., Fatulrachman,, Aftitah, V. B., Fadlitha, V. B., Sato, N., Fujimura, T., Takimoto, H..
J Dermatol, 46 (10) :853-858 (2019)
https://www.ncbi.nlm.nih.gov/pubmed/31432529
Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response.
Ryuichi Nagashima, Hitomi Kosai, Masahiro Masuo, Keiko Izumiyama, Taketo Noshikawaji, Motoko Morimoto, Satoru Kumaki, Yasunari Miyazaki, Hozumi Motohashi, Masayuki Yamamoto, Nobuyuki Tanaka.
Journal of immunology, 202 (5) :1331-1339 (2019)
doi: 10.4049/jimmunol.1801180.
The unique tropism of Mycobacterium leprae to the nasal epithelial cells can be explained by the mammalian cell entry protein 1A
Fadlitha, V. B., Yamamoto, F., Idris, I., Dahlan, H., Sato, N., Aftitah, V. B., Febriyanda, A., Fujimura, T., Takimoto, H..
PLoS Negl Trop Dis, 13 (3) :e0006704 (2019)
https://www.ncbi.nlm.nih.gov/pubmed/30835734
Potent Inhibitory Effects of Quercetin on Inflammatory Responses of Collagen-Induced Arthritis in Mice
Kawaguchi, K., Kaneko, M., Miyake, R., Takimoto, H., Kumazawa, Y..
Endocr Metab Immune Disord Drug Targets, 19 (3) :308-315 (2019)
https://www.ncbi.nlm.nih.gov/pubmed/30727927
Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.
Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M..
Journal of Hepatology, 69 (1) :110-120 (2018)
doi: 10.1016/j.jhep.2018.02.009
Modification of lipid A structure and activity by the introduction of palmitoyltransferase gene to the acyltransferase-knockout mutant of Escherichia coli
Sugawara, T., Onoue, S., Takimoto, H., Kawahara, K..
Microbiol Immunol, 62 (8) :497-506 (2018)
https://www.ncbi.nlm.nih.gov/pubmed/29932223
Role of T-bet, the master regulator of Th1 cells, in the cytotoxicity of murine CD4+ T cells.
Eshima K, Misawa K, Ohashi C, Iwabuchi K..
Microbiology and Immunology, 65 (5) :348-356 (2018)
doi: 10.1111/1348-0421.12586
Euglena gracilis Z and its carbohydrate storage substance relieve arthritis symptoms by modulating Th17 immunity
Suzuki, K., Nakashima, A., Igarashi, M., Saito, K., Konno, M., Yamazaki, N., Takimoto, H..
PLoS One, 13 (2) :e0191462 (2018)
https://www.ncbi.nlm.nih.gov/pubmed/29389956
Oral administration of Euglena gracilis Z and its carbohydrate storage substance provides survival protection against influenza virus infection in mice
Nakashima, A., Suzuki, K., Asayama, Y., Konno, M., Saito, K., Yamazaki, N., Takimoto, H..
Biochem Biophys Res Commun, 494 (1月2日) :379-383 (2017)
https://www.ncbi.nlm.nih.gov/pubmed/28974421
Morphometrical and Morphological Alterations of Human Leukocytes Exposed to 1.8 GHz Electromagnetic Radiations: In Vitro Protective Effects Induced by Polyphenols
Biagi, P. F., Boffola, S., Stefanelli, R., Schiavulli, L., Ligonzo, T., Casamassima, G., Pappagallo, M. T., Kawaguchi, K., Takimoto, H., Kumazawa, Y., Fontana, S., Laforgia, F., Russo, M. A., Magrone, T., Jirillo, E..
Endocr Metab Immune Disord Drug Targets, 16 (3) :189-196 (2016)
https://www.ncbi.nlm.nih.gov/pubmed/27697072
BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils.
Kojo K, Ito Y, Eshima K, Nishizawa N, Ohkubo H, Yokomizo T, Shimizu T, Watanabe M, Majima M..
Scientific Reports, 6 :29650 (2016)
doi: 10.1038/srep29650
Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses.
Makoto Kubo, Ryuichi Nagashima, Etsuro Ohta, Tatsunori Maekawa, Yumiko Isobe, Mitsue Kurihara, Koji Eshima, Kazuya Iwabuchi, Toshikuni Sasaoka, Sadahiro Azuma, Heather L Melrose, Matthew J Farrer, Fumiya Obata.
Journal of neuroimmunology, 292 :1月8日 (2016)
doi: 10.1016/j.jneuroim.2016.01.005.
Analysis of possible suppression mechanisms for HIV-1 replication in CD4+ T cells co-cultured with alloantigen-stimulated CD8+ T cells.
Ryuichi Nagashima, Fumiya Obata, Makoto Kubo.
The Kitasato Medical Journal, 46 (1) :32-39 (2016)
Differential dependence on nuclear factor-κB-inducing kinase among natural killer T-cell subsets in their development.
Noma H, Eshima K*, Satoh M, Iwabuchi K.
Immunology, 146 (1) :88-99 (2015)
doi: 10.1111/imm.12484.
Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions.
Amano H, Ito Y, Eshima K, Kato S, Ogawa F, Hosono K, Oba K, Tamaki H, Sakagami H, Shibuya M, Narumiya S, Majima M..
Cardiovascular Research, 107 (4) :509-521 (2015)
doi: 10.1093/cvr/cvv139
Prostanoid induces premetastatic niche in regional lymph nodes.
Ogawa F*, Amano H*, Eshima K*, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiya S, Majima M..
Journal of Clinical Investigation, 124 (11) :4882-4894 (2014)
doi: 10.1172/JCI73530
Allo-antigen stimulated CD8+ T-cells suppress NF-κB and Ets-1 DNA binding activity, and inhibit phosphorylated NF-κB p65 nuclear localization in CD4+ T-cells.
Ryuichi Nagashima, Fumitaka Kawakami, Shinichiro Takahashi, Fumiya Obata, Makoto Kubo.
Viral immunology, 27 (6) :305-315 (2014)
doi: 10.1089/vim.2013.0113.
Biodistribution of locally or systemically transplanted osteoblast-like cells.
Okabe Y T, Kondo T, Mishima K, Hayase Y, Kato K, Mizuno M, Ishiguro N and Kitoh H.
Bone and Joint Research, 3 :76-81 (2014)
https://pubmed.ncbi.nlm.nih.gov/24652780/
doi: 10.1302/2046-3758.33.2000257.
Significant Involvement of NF-κB-inducing Kinase in Proper Differentiation of αβ and γδ T cells.
Eshima K, Okabe M, Kajiura S, Noma H, Shinohara N, Iwabuchi K..
Immunology, 141 (2) :222-232 (2014)
doi: 10.1111/imm.12186
Potential use of dietary natural products, especially polyphenols, for improving type-1 allergic symptoms
Kumazawa, Y., Takimoto, H., Matsumoto, T., Kawaguchi, K..
Curr Pharm Des, 20 (6) :857-63 (2013)
https://www.ncbi.nlm.nih.gov/pubmed/23701564
Immunomodulating and anti-allergic effects of Negroamaro and Koshu Vitis vinifera fermented grape marc (FGM)
Marzulli, Giuseppe, Magrone, Thea, Vonghia, Luisa, Kaneko, Masahiro, Takimoto, Hiroaki, Kumazawa, Yoshio, Jirillo, Emilio.
Curr Pharm Des, 20 (6) :864-8 (2013)
https://www.ncbi.nlm.nih.gov/pubmed/23701568