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獣医薬理学研究室

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研究課題

・高血圧、心不全、動脈硬化、糖尿病性血管障害の病態機序解明と治療薬の探索:心血管生物学的検討 ・新規脂肪組織由来サイトカイン(アディポサイトカイン)の心血管系における役割 ・心臓リモデリングと細胞外マトリックス分解産物との関連に関する研究 ・生理活性因子・薬物の心・血管反応性とイオンチャネル電流に及ぼす影響 ・細胞外小胞(EV)の心血管系における役割

トピックス

(受賞歴) 北里研究所 第17回森村豊明会奨励賞(2019年度) 第162回日本獣医学会学術集会 比較薬理毒性学会奨励賞(2019年度) 日本薬理学会 第33回学術奨励賞(2018年度) 日本獣医学会 2017‐2018年度 獣医学奨励賞 日本獣医学会 2016‐2017年度 獣医学奨励賞 日本獣医学会 2015‐2016年度 獣医学奨励賞

研究業績

(2020年)
1. Yamamoto A, Matsumoto K, Hori K, Kameshima S, Yamaguchi N, Okada S, Okada M, and Yamawaki H. Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain. Pflugers Archiv - Eur J Physiol, 2020. In Press.

2. Omori A, Goshima M, Kakuda C, Kodama T, Otani K, Okada M, and Yamawaki H. Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. Pflugers Archiv - Eur J Physiol 472: 335-342, 2020.

3. Sugiyama A, Okada M, and Yamawaki H. Canstatin suppresses isoproterenol-induced cardiac hypertrophy through inhibition of calcineurin/nuclear factor of activated T-cells pathway in rats. Eur J Pharmacol 871: 172849, 2020.

(2019年)
1. Otani K, Fujioka Y, Okada M, and Yamawaki H. Optimal isolation method of small extracellular vesicles from rat plasma. Int J Mol Sci 20: 4780, 2019.

2. Kameshima S, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts. Apoptosis 24: 359-368, 2019.

3. Imoto K, Okada M, and Yamawaki H. Periostin mediates right ventricular failure through induction of inducible nitric oxide synthase expression in right ventricular fibroblasts from monocrotaline-induced pulmonary arterial hypertensive rats. Int J Mol Sci 20: 62, 2019.

(2018年)
1. Otani K, Yokoya M, Kodama T, Hori K, Matsumoto K, Okada M, and Yamawaki H. Plasma exosomes regulate systemic blood pressure in rats. Biochem Biophys Res Commun 503: 776-783, 2018.

2. Imoto K, Okada M, and Yamawaki H. Characterization of fibroblasts from hypertrophied right ventricle of pulmonary hypertensive rats. Pflugers Archiv - Eur J Physiol 470: 1405-1417, 2018.

3. Kodama T, Okada M, and Yamawaki H. Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery. J Pharmacol Sci 137: 86-92, 2018.

4. Sugiyama A, Hirano Y, Okada M, and Yamawaki H. Endostatin stimulates proliferation and migration of myofibroblasts isolated from myocardial infarction model rats. Int J Mol Sci 19: 741, 2018.

(2017年)
1. Sugiyama A, Okada M, and Yamawaki H. Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats. Eur J Pharmacol 807: 32-43, 2017.

2. Yasuda J, Okada M, and Yamawaki H. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts. Eur J Pharmacol 807: 64-70, 2017.

3. Okada M, Murata N and Yamawaki H. Canstatin stimulates migration of rat cardiac fibroblasts via secretion of matrix metalloproteinase-2. Am J Physiol-Cell Physiol 312: C199-C208, 2017.

(2016年)
1. Okada M, Morioka S, Kanazawa H, and Yamawaki H. Canstatin inhibits isoproterenol-induced apoptosis through preserving mitochondrial morphology in differentiated H9c2 cardiomyoblasts. Apoptosis 21: 887-895, 2016.

2. Kameshima S, Sakamoto Y, Okada M, and Yamawaki H. Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodeling in spontaneously hypertensive rats. Acta Physiol (Oxf) 217: 120-129, 2016.

3.Imoto K, Kumatani S, Okada M, and Yamawaki H. Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca2+ channel . Pflugers Archiv - Eur J Physiol 468: 1259-1270, 2016.

(2015年)
1. Kunimoto H, Kazama K, Takai M, Oda M, Okada M, and Yamawaki H. Chemerin promotes proliferation and migration of vascular smooth muscle and increases mouse blood pressure. Am J Physiol-Heart and Circulatory Physiology 309: H1017-H1028, 2015.

2. Kameshima S, Kazama K, Okada M, and Yamawaki H. Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling. Am J Physiol-Heart and Circulatory Physiology 308: H1298-H1305, 2015.

3. Kazama K, Okada M, and Yamawaki H. Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species. Biochem Biophys Res Commun 457: 602-607, 2015.

4. Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, and Yamawaki H. Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells. Acta Physiol (Oxf) 213: 472-480, 2015.

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